Weill Cornell Graduate School of Medical Sciences 3 articles published in JoVE Neuroscience A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments Suniyya A. Waraich1, Jonathan D. Victor2 1Program in Neuroscience, Weill Cornell Graduate School of Medical Sciences, 2Feil Family Brain and Mind Research Institute, Weill Cornell Medical College The protocol presents an experimental psychophysics paradigm to obtain large quantities of similarity judgments, and an accompanying analysis workflow. The paradigm probes context effects and enables modeling of similarity data in terms of Euclidean spaces of at least five dimensions. Immunology and Infection Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist Elisa Sanchez1,2, Morgan Huse1 1Immunology Program, Memorial Sloan-Kettering Cancer Center, 2Weill-Cornell Graduate School of Medical Sciences This protocol describes an imaging-based method to activate T lymphocytes using photoactivatable peptide-MHC, enabling precise spatiotemporal control of T cell activation. Behavior Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference Kathryn C. Schierberl1,2, Anjali M. Rajadhyaksha1,2 1Graduate Program in Neuroscience, Weill Cornell Graduate School of Biomedical Sciences, 2Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medical College This article describes how to microinject viral vectors into mouse brain and then test in a conditioned place preference paradigm that includes an acquisition, extinction and reinstatement phase.
