Filip Lardon Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON) University of Antwerp Biography Publications Institution JoVE Articles Filip Lardon has not added a biography. If you are Filip Lardon and would like to personalize this page please email our Author Liaison for assistance. Publications OrBITS: Label-free and Time-lapse Monitoring of Patient Derived Organoids for Advanced Drug Screening Cellular Oncology (Dordrecht). Dec, 2022 | Pubmed ID: 36508089 The Prognostic Impact of the Immune Signature in Head and Neck Squamous Cell Carcinoma Frontiers in Immunology. 2022 | Pubmed ID: 36268020 The Effect of Local Non-thermal Plasma Therapy on the Cancer-immunity Cycle in a Melanoma Mouse Model Bioengineering & Translational Medicine. Sep, 2022 | Pubmed ID: 36176603 Prognostic Implications of Cellular Senescence in Resected Non-small Cell Lung Cancer Translational Lung Cancer Research. Aug, 2022 | Pubmed ID: 36090630 Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care Therapy Cancers. Aug, 2022 | Pubmed ID: 36077610 NTRK Gene Fusion Detection in a Pan-Cancer Setting Using the Idylla GeneFusion Assay The Journal of Molecular Diagnostics : JMD. Jul, 2022 | Pubmed ID: 35550184 Targeting Hedgehog Signaling in Pancreatic Ductal Adenocarcinoma Pharmacology & Therapeutics. Aug, 2022 | Pubmed ID: 34999181 Evaluation of Cytologic Sample Preparations for Compatibility With Nucleic Acid Analysis American Journal of Clinical Pathology. Feb, 2022 | Pubmed ID: 34542583 Recent Insights in the PI3K/Akt Pathway As a Promising Therapeutic Target in Combination with EGFR-targeting Agents to Treat Head and Neck Squamous Cell Carcinoma Medicinal Research Reviews. Jan, 2022 | Pubmed ID: 33928670 Characterization of Acquired Nutlin-3 Resistant Non-small Cell Lung Cancer Cells Cancer Drug Resistance (Alhambra, Calif.). 2021 | Pubmed ID: 35582010 Auranofin and Cold Atmospheric Plasma Synergize to Trigger Distinct Cell Death Mechanisms and Immunogenic Responses in Glioblastoma Cells. Oct, 2021 | Pubmed ID: 34831159 The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An Study on a Novel Combination Strategy Frontiers in Oncology. 2021 | Pubmed ID: 34568028 The Right Partner in Crime: Unlocking the Potential of the Anti-EGFR Antibody Cetuximab Combination With Natural Killer Cell Chartering Immunotherapeutic Strategies Frontiers in Immunology. 2021 | Pubmed ID: 34557197 A Systematic Review on Poly(I:C) and Poly-ICLC in Glioblastoma: Adjuvants Coordinating the Unlocking of Immunotherapy Journal of Experimental & Clinical Cancer Research : CR. Jun, 2021 | Pubmed ID: 34172082 Cancer-Associated Fibroblasts As a Common Orchestrator of Therapy Resistance in Lung and Pancreatic Cancer Cancers. Feb, 2021 | Pubmed ID: 33673405 Targeting the PD-1 Axis with Pembrolizumab for Recurrent or Metastatic Cancer of the Uterine Cervix: A Brief Update International Journal of Molecular Sciences. Feb, 2021 | Pubmed ID: 33670397 Novel Combination Immunotherapy for Pancreatic Cancer: Potent Anti-tumor Effects with CD40 Agonist and Interleukin-15 Treatment Clinical & Translational Immunology. 2020 | Pubmed ID: 32821382 Cetuximab-induced Natural Killer Cell Cytotoxicity in Head and Neck Squamous Cell Carcinoma Cell Lines: Investigation of the Role of Cetuximab Sensitivity and HPV Status British Journal of Cancer. Sep, 2020 | Pubmed ID: 32541873 Specialized Blood Collection Tubes for Liquid Biopsy: Improving the Pre-analytical Conditions Molecular Diagnosis & Therapy. Feb, 2020 | Pubmed ID: 31838654 The Potential and Controversy of Targeting STAT Family Members in Cancer Seminars in Cancer Biology. Feb, 2020 | Pubmed ID: 31605750 The Role of C-Met As a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies Molecules (Basel, Switzerland). Dec, 2019 | Pubmed ID: 31817278 Radiosensitization of Non-Small Cell Lung Cancer Cells by the Plk1 Inhibitor Volasertib Is Dependent on the P53 Status Cancers. Nov, 2019 | Pubmed ID: 31795121 Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells Cancers. Oct, 2019 | Pubmed ID: 31635070 The Benefit of Reactivating P53 Under MAPK Inhibition on the Efficacy of Radiotherapy in Melanoma Cancers. Aug, 2019 | Pubmed ID: 31374895 Decrease in Phospho-PRAS40 Plays a Role in the Synergy Between Erlotinib and Crizotinib in an EGFR and CMET Wild-type Squamous Non-small Cell Lung Cancer Cell Line Biochemical Pharmacology. Aug, 2019 | Pubmed ID: 31078602 RANK-RANKL Signaling in Cancer of the Uterine Cervix: A Review International Journal of Molecular Sciences. May, 2019 | Pubmed ID: 31052546 Multicenter Phase II Clinical Trial of Isolated Lung Perfusion in Patients With Lung Metastases The Annals of Thoracic Surgery. Jul, 2019 | Pubmed ID: 30951699 Circulating Cell-Free DNA and RNA Analysis As Liquid Biopsy: Optimal Centrifugation Protocol Cancers. Mar, 2019 | Pubmed ID: 30935089 In vitro Study of the Polo-like Kinase 1 Inhibitor Volasertib in Non-small-cell Lung Cancer Reveals a Role for the Tumor Suppressor P53 Molecular Oncology. May, 2019 | Pubmed ID: 30859681 RANK/RANKL Signaling Inhibition May Improve the Effectiveness of Checkpoint Blockade in Cancer Treatment Critical Reviews in Oncology/hematology. Jan, 2019 | Pubmed ID: 30661662 Overcoming Intrinsic and Acquired Cetuximab Resistance in RAS Wild-Type Colorectal Cancer: An In Vitro Study on the Expression of HER Receptors and the Potential of Afatinib Cancers. Jan, 2019 | Pubmed ID: 30650638 Unveiling a CD70-positive Subset of Cancer-associated Fibroblasts Marked by Pro-migratory Activity and Thriving Regulatory T Cell Accumulation Oncoimmunology. 2018 | Pubmed ID: 29900042 Monitoring EGFR TKI Resistance in Real Time Using DdPCR-based Liquid Biopsy: a Case Report Journal of Clinical Pathology. Aug, 2018 | Pubmed ID: 29853531 Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant P53 and Can Be Overcome by Induction of Oxidative Stress Cancers. Apr, 2018 | Pubmed ID: 29690507 Simultaneous Targeting of EGFR, HER2, and HER4 by Afatinib Overcomes Intrinsic and Acquired Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cell Lines Molecular Oncology. Jun, 2018 | Pubmed ID: 29603584 Poly(I:C) Primes Primary Human Glioblastoma Cells for an Immune Response Invigorated by PD-L1 Blockade Oncoimmunology. 2018 | Pubmed ID: 29399410 Preclinical Data on the Combination of Cisplatin and Anti-CD70 Therapy in Non-small Cell Lung Cancer As an Excellent Match in the Era of Combination Therapy Oncotarget. Sep, 2017 | Pubmed ID: 29088768 Interleukin-15 Stimulates Natural Killer Cell-mediated Killing of Both Human Pancreatic Cancer and Stellate Cells Oncotarget. Aug, 2017 | Pubmed ID: 28915646 Dual Targeting of Epidermal Growth Factor Receptor and HER3 by MEHD7945A As Monotherapy or in Combination with Cisplatin Partially Overcomes Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cell Lines Cancer Biotherapy & Radiopharmaceuticals. Sep, 2017 | Pubmed ID: 28910149 SNP309 and SNP285 Act As Negative Prognostic Markers for Non-small Cell Lung Cancer Adenocarcinoma Patients Journal of Cancer. 2017 | Pubmed ID: 28819417 Towards Prognostic Profiling of Non-Small Cell Lung Cancer: New Perspectives on the Relevance of Polo-Like Kinase 1 Expression, the Mutation Status and Hypoxia Journal of Cancer. 2017 | Pubmed ID: 28638459 Deep Sequencing of the TP53 Gene Reveals a Potential Risk Allele for Non-small Cell Lung Cancer and Supports the Negative Prognostic Value of TP53 Variants Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Feb, 2017 | Pubmed ID: 28240049 A Comparison of Cell-Free DNA Isolation Kits: Isolation and Quantification of Cell-Free DNA in Plasma The Journal of Molecular Diagnostics : JMD. Jan, 2017 | Pubmed ID: 27865784 Better to Be Alone Than in Bad Company: The Antagonistic Effect of Cisplatin and Crizotinib Combination Therapy in Non-small Cell Lung Cancer World Journal of Clinical Oncology. Dec, 2016 | Pubmed ID: 28008383 Primary Skeletal Muscle Myoblasts from Chronic Heart Failure Patients Exhibit Loss of Anti-inflammatory and Proliferative Activity BMC Cardiovascular Disorders. May, 2016 | Pubmed ID: 27228977 Efficacy Screening of Gloriosa Superba Extracts in a Murine Pancreatic Cancer Model Using (18)F-FDG PET/CT for Monitoring Treatment Response Cancer Biotherapy & Radiopharmaceuticals. Apr, 2016 | Pubmed ID: 27093343 APR-246 (PRIMA-1(MET)) Strongly Synergizes with AZD2281 (olaparib) Induced PARP Inhibition to Induce Apoptosis in Non-small Cell Lung Cancer Cell Lines Cancer Letters. Jun, 2016 | Pubmed ID: 26975633 TP53 and MDM2 Genetic Alterations in Non-small Cell Lung Cancer: Evaluating Their Prognostic and Predictive Value Critical Reviews in Oncology/hematology. Mar, 2016 | Pubmed ID: 26689115 In Vitro and in Vivo Investigations on the Antitumour Activity of Chelidonium Majus Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Dec, 2015 | Pubmed ID: 26626193 Immune Checkpoint Modulation in Colorectal Cancer: What's New and What to Expect Journal of Immunology Research. 2015 | Pubmed ID: 26605342 Establishment and Characterization of Cetuximab Resistant Head and Neck Squamous Cell Carcinoma Cell Lines: Focus on the Contribution of the AP-1 Transcription Factor American Journal of Cancer Research. 2015 | Pubmed ID: 26269754 The MDM2-inhibitor Nutlin-3 Synergizes with Cisplatin to Induce P53 Dependent Tumor Cell Apoptosis in Non-small Cell Lung Cancer Oncotarget. Sep, 2015 | Pubmed ID: 26125230 The Hypoxic Tumor Microenvironment and Drug Resistance Against EGFR Inhibitors: Preclinical Study in Cetuximab-sensitive Head and Neck Squamous Cell Carcinoma Cell Lines BMC Research Notes. 2015 | Pubmed ID: 26032726 Decreased Expression of ABAT and STC2 Hallmarks ER-positive Inflammatory Breast Cancer and Endocrine Therapy Resistance in Advanced Disease Molecular Oncology. Jun, 2015 | Pubmed ID: 25771305 Expression Profiling of Migrated and Invaded Breast Cancer Cells Predicts Early Metastatic Relapse and Reveals Krüppel-like Factor 9 As a Potential Suppressor of Invasive Growth in Breast Cancer Oncoscience. 2014 | Pubmed ID: 25593984 Overcoming Cetuximab Resistance in HNSCC: the Role of AURKB and DUSP Proteins Cancer Letters. Nov, 2014 | Pubmed ID: 25192874 The Radiosensitising Effect of Gemcitabine and Its Main Metabolite DFdU Under Low Oxygen Conditions is in Vitro Not Dependent on Functional HIF-1 Protein BMC Cancer. 2014 | Pubmed ID: 25128202 Phase II Multicenter Clinical Trial of Pulmonary Metastasectomy and Isolated Lung Perfusion with Melphalan in Patients with Resectable Lung Metastases Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Oct, 2014 | Pubmed ID: 25105436 Mutation Analysis of Genes in the EGFR Pathway in Head and Neck Cancer Patients: Implications for Anti-EGFR Treatment Response BMC Research Notes. 2014 | Pubmed ID: 24899223 Synthesis and in Vivo Preclinical Evaluation of an (18)F Labeled UPA Inhibitor As a Potential PET Imaging Agent Nuclear Medicine and Biology. Jul, 2014 | Pubmed ID: 24768145 Study Assessing the Quality of Quantification of Estrogen Receptor Protein Expression by Immunohistochemistry and Gene Expression in Breast Cancer Pathology Research International. 2014 | Pubmed ID: 24734208 Pharmacological Levels of Withaferin A (Withania Somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells PloS One. 2014 | Pubmed ID: 24498382 Krüppel-like Factors in Cancer Progression: Three Fingers on the Steering Wheel Oncotarget. Jan, 2014 | Pubmed ID: 24429391 Anti-epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance The Oncologist. 2013 | Pubmed ID: 23821327 Expression Analysis on Archival Material Revisited: Isolation and Quantification of RNA Extracted from FFPE Samples Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. Mar, 2013 | Pubmed ID: 23370428 The Intriguing Interplay Between Therapies Targeting the Epidermal Growth Factor Receptor, the Hypoxic Microenvironment and Hypoxia-inducible Factors Current Pharmaceutical Design. 2013 | Pubmed ID: 22973959 Probiotics Enhance the Clearance of Human Papillomavirus-related Cervical Lesions: a Prospective Controlled Pilot Study European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP). Jan, 2013 | Pubmed ID: 22706167 Comparative Analysis of Dynamic Cell Viability, Migration and Invasion Assessments by Novel Real-time Technology and Classic Endpoint Assays PloS One. 2012 | Pubmed ID: 23094027 The Interaction Between ER and NFκB in Resistance to Endocrine Therapy Breast Cancer Research : BCR. 2012 | Pubmed ID: 22963717 Tumor Cells and Tumor-associated Macrophages: Secreted Proteins As Potential Targets for Therapy Clinical & Developmental Immunology. 2011 | Pubmed ID: 22162712 Expression Analysis on Archival Material: Comparison of 5 Commercially Available RNA Isolation Kits for FFPE Material Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. Dec, 2011 | Pubmed ID: 22089347 Immune Cells in Colorectal Cancer: Prognostic Relevance and Role of MSI Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society. Dec, 2011 | Pubmed ID: 21618031 Retention of the in Vitro Radiosensitizing Potential of Gemcitabine Under Anoxic Conditions, in P53 Wild-type and P53-deficient Non-small-cell Lung Carcinoma Cells International Journal of Radiation Oncology, Biology, Physics. Jun, 2011 | Pubmed ID: 21377279 The Presence of Y Chromosomal Deoxyribonucleic Acid in the Female Vaginal Swab: Possible Implications for Human Papillomavirus Testing Cancer Epidemiology. Feb, 2011 | Pubmed ID: 21095173 Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation Future Oncology (London, England). Sep, 2010 | Pubmed ID: 20919831 In Vitro Study on the Schedule-dependency of the Interaction Between Pemetrexed, Gemcitabine and Irradiation in Non-small Cell Lung Cancer and Head and Neck Cancer Cells BMC Cancer. Aug, 2010 | Pubmed ID: 20723210 A Review of the Most Promising Biomarkers in Colorectal Cancer: One Step Closer to Targeted Therapy The Oncologist. 2010 | Pubmed ID: 20584808 Tumor Infiltrating Lymphocytes: an Intriguing Player in the Survival of Colorectal Cancer Patients BMC Immunology. Apr, 2010 | Pubmed ID: 20385003 Detection of HPV and the Role of P16INK4A Overexpression As a Surrogate Marker for the Presence of Functional HPV Oncoprotein E7 in Colorectal Cancer BMC Cancer. Mar, 2010 | Pubmed ID: 20346145 Counting Clonogenic Assays from Normoxic and Anoxic Irradiation Experiments Manually or by Using Densitometric Software Physics in Medicine and Biology. Apr, 2010 | Pubmed ID: 20208097 Everything You Always Wanted to Know About HPV (but Could Not Ask Your Doctor) Patient Education and Counseling. Oct, 2010 | Pubmed ID: 20056371 Chemoradiation Interactions Under Reduced Oxygen Conditions: Cellular Characteristics of an in Vitro Model Cancer Letters. Dec, 2009 | Pubmed ID: 19540039 Microsatellite Instability in Sporadic Colon Carcinomas Has No Independent Prognostic Value in a Belgian Study Population European Journal of Cancer (Oxford, England : 1990). Oct, 2008 | Pubmed ID: 18707864 Comparative Study of the Radiosensitizing and Cell Cycle Effects of Vinflunine and Vinorelbine, in Vitro BMC Cancer. Feb, 2008 | Pubmed ID: 18312675 Detection of Microsatellite Instability in Colorectal Cancer Using an Alternative Multiplex Assay of Quasi-monomorphic Mononucleotide Markers The Journal of Molecular Diagnostics : JMD. Mar, 2008 | Pubmed ID: 18258928 Further Mechanistic Unravelling of the Influence of the Cell Cycle Effects on the Radiosensitising Mechanism of Vinflunine, in Vitro Cancer Chemotherapy and Pharmacology. Jul, 2008 | Pubmed ID: 17899084 Review: Implications of in Vitro Research on the Effect of Radiotherapy and Chemotherapy Under Hypoxic Conditions The Oncologist. Jun, 2007 | Pubmed ID: 17602059 The Relation Between Deoxycytidine Kinase Activity and the Radiosensitising Effect of Gemcitabine in Eight Different Human Tumour Cell Lines BMC Cancer. May, 2006 | Pubmed ID: 16734894 Comparison of Three Commonly Used PCR-based Techniques to Analyze MSI Status in Sporadic Colorectal Cancer Journal of Clinical Laboratory Analysis. 2006 | Pubmed ID: 16538640 The Radiosensitising Effect of Difluorodeoxyuridine, a Metabolite of Gemcitabine, in Vitro Cancer Chemotherapy and Pharmacology. Aug, 2006 | Pubmed ID: 16331496 Cell Cycle Effects of Vinflunine, the Most Recent Promising Vinca Alkaloid, and Its Interaction with Radiation, in Vitro Cancer Chemotherapy and Pharmacology. Aug, 2006 | Pubmed ID: 16317558 Combined Pap and HPV Testing in Primary Screening for Cervical Abnormalities: Should HPV Detection Be Delayed Until Age 35? European Journal of Cancer (Oxford, England : 1990). Nov, 2005 | Pubmed ID: 16242316 Unraveling the Mechanism of Radiosensitization by Gemcitabine: the Role of TP53 Radiation Research. Nov, 2005 | Pubmed ID: 16238441 Combined Modality Therapy of Gemcitabine and Radiation The Oncologist. Jan, 2005 | Pubmed ID: 15632251 The Prevalence of the Human Papillomavirus in Cervix and Vagina in Low-risk and High-risk Populations Scandinavian Journal of Infectious Diseases. 2004 | Pubmed ID: 15307568 Can Cervical Cancer Screening Be Stopped at 50? The Prevalence of HPV in Elderly Women International Journal of Cancer. Jan, 2004 | Pubmed ID: 14639612 Cell Cycle Effect of Gemcitabine and Its Role in the Radiosensitizing Mechanism in Vitro International Journal of Radiation Oncology, Biology, Physics. Nov, 2003 | Pubmed ID: 14575839 Comparison of the Sulforhodamine B Assay and the Clonogenic Assay for in Vitro Chemoradiation Studies Cancer Chemotherapy and Pharmacology. Mar, 2003 | Pubmed ID: 12655440 Messenger RNA Electroporation of Human Monocytes, Followed by Rapid in Vitro Differentiation, Leads to Highly Stimulatory Antigen-loaded Mature Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Aug, 2002 | Pubmed ID: 12165485 Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis Maxim Le Compte1, Edgar Cardenas De La Hoz2, Sofía Peeters1, Evelien Smits1, Filip Lardon1, Geert Roeyen1,3, Steve Vanlanduit2, Hans Prenen1,4, Marc Peeters1,4, Abraham Lin1,5, Christophe Deben1 1Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, 2Industrial Vision Lab, University of Antwerp, 3Department of Hepatobiliary Transplantation and Endocrine Surgery, University Hospital Antwerp (UZA), 4Department of Oncology, University Hospital Antwerp (UZA), 5Plasma Lab for Applications in Sustainability and Medicine ANTwerp (PLASMANT), University of Antwerp JoVE 64434 Ricerca sul cancro
Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis Maxim Le Compte1, Edgar Cardenas De La Hoz2, Sofía Peeters1, Evelien Smits1, Filip Lardon1, Geert Roeyen1,3, Steve Vanlanduit2, Hans Prenen1,4, Marc Peeters1,4, Abraham Lin1,5, Christophe Deben1 1Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, 2Industrial Vision Lab, University of Antwerp, 3Department of Hepatobiliary Transplantation and Endocrine Surgery, University Hospital Antwerp (UZA), 4Department of Oncology, University Hospital Antwerp (UZA), 5Plasma Lab for Applications in Sustainability and Medicine ANTwerp (PLASMANT), University of Antwerp JoVE 64434 Ricerca sul cancro
