Huaxin Sheng Multidisciplinary Brain Protection Program, Department of Anesthesiology Duke University Medical Center Biography Publications Institution JoVE Articles Huaxin Sheng has not added a biography. If you are Huaxin Sheng and would like to personalize this page please email our Author Liaison for assistance. Publications A Mast Cell-thermoregulatory Neuron Circuit Axis Regulates Hypothermia in Anaphylaxis Science Immunology. Mar, 2023 | Pubmed ID: 36930731 Beneficial Effects of Neuronal ATF6 Activation in Permanent Ischemic Stroke Frontiers in Cellular Neuroscience. 2022 | Pubmed ID: 36313623 SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats Neurocritical Care. Oct, 2022 | Pubmed ID: 36224490 Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats Biology. Jun, 2022 | Pubmed ID: 36101338 Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics Molecules (Basel, Switzerland). Jul, 2022 | Pubmed ID: 35807529 Single-cell Transcriptomic Analysis of the Immune Cell Landscape in the Aged Mouse Brain After Ischemic Stroke Journal of Neuroinflammation. Apr, 2022 | Pubmed ID: 35392936 Effects of Long-Term Vagus Nerve Electrical Stimulation Therapy on Acute Cerebral Infarction and Neurological Function Recovery in Post MCAO Mice Oxidative Medicine and Cellular Longevity. 2022 | Pubmed ID: 35391930 Post-ischemia Common Carotid Artery Occlusion Worsens Memory Loss, but Not Sensorimotor Deficits, in Long-term Survived Stroke Mice Brain Research Bulletin. Jun, 2022 | Pubmed ID: 35304288 Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy Neuromodulation : Journal of the International Neuromodulation Society. Apr, 2022 | Pubmed ID: 35131154 Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice Shock (Augusta, Ga.). Nov, 2021 | Pubmed ID: 34652341 Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice Journal of the American Heart Association. Jun, 2021 | Pubmed ID: 34111943 Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation Journal of the American Heart Association. Jun, 2021 | Pubmed ID: 34013738 Increasing O-GlcNAcylation is Neuroprotective in Young and Aged Brains After Ischemic Stroke Experimental Neurology. May, 2021 | Pubmed ID: 33600817 Cardiac Arrest and Resuscitation Activates the Hypothalamic-pituitary-adrenal Axis and Results in Severe Immunosuppression Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2021 | Pubmed ID: 32787543 Small Ubiquitin-like Modifier 2 (SUMO2) is Critical for Memory Processes in Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32910521 MCC950, a Selective NLPR3 Inflammasome Inhibitor, Improves Neurologic Function and Survival After Cardiac Arrest and Resuscitation Journal of Neuroinflammation. Aug, 2020 | Pubmed ID: 32867797 PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis Stroke. May, 2020 | Pubmed ID: 32212900 Chemogenetics-mediated Acute Inhibition of Excitatory Neuronal Activity Improves Stroke Outcome Experimental Neurology. Apr, 2020 | Pubmed ID: 31962128 Stroke Prevents Exercise-Induced Gains in Bone Microstructure But Not Composition in Mice Journal of Biomechanical Engineering. Dec, 2019 | Pubmed ID: 31596925 Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice Journal of the American Heart Association. 09, 2018 | Pubmed ID: 30371162 High-speed Widefield Photoacoustic Microscopy of Small-animal Hemodynamics Biomedical Optics Express. Oct, 2018 | Pubmed ID: 30319896 Novel Treatment of Cryptococcal Meningitis Via Neurapheresis Therapy The Journal of Infectious Diseases. Aug, 2018 | Pubmed ID: 29788431 Ubc9 Overexpression and SUMO1 Deficiency Blunt Inflammation After Intestinal Ischemia/reperfusion Laboratory Investigation; a Journal of Technical Methods and Pathology. Jun, 2018 | Pubmed ID: 29472640 Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice Aging and Disease. Feb, 2018 | Pubmed ID: 29392079 Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression Via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2017 | Pubmed ID: 28505619 XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G Stroke. Jun, 2017 | Pubmed ID: 28487326 Anesthetic Neuroprotection? It's Complicated Anesthesiology. Apr, 2017 | Pubmed ID: 28182586 Neuron-specific SUMO Knockdown Suppresses Global Gene Expression Response and Worsens Functional Outcome After Transient Forebrain Ischemia in Mice Neuroscience. Feb, 2017 | Pubmed ID: 27919694 Activation of the ATF6 Branch of the Unfolded Protein Response in Neurons Improves Stroke Outcome Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2017 | Pubmed ID: 27217380 Targeting the SUMO Pathway for Neuroprotection in Brain Ischaemia Stroke and Vascular Neurology. Sep, 2016 | Pubmed ID: 28959470 Anesthesia in Experimental Stroke Research Translational Stroke Research. Oct, 2016 | Pubmed ID: 27534542 Natural Allelic Variation of the IL-21 Receptor Modulates Ischemic Stroke Infarct Volume The Journal of Clinical Investigation. Aug, 2016 | Pubmed ID: 27400126 Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats Neurocritical Care. Oct, 2016 | Pubmed ID: 26896093 Video Training and Certification Program Improves Reliability of Postischemic Neurologic Deficit Measurement in the Rat Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Dec, 2016 | Pubmed ID: 26661238 O-linked β-N-acetylglucosamine Modification of Proteins is Activated in Post-ischemic Brains of Young but Not Aged Mice: Implications for Impaired Functional Recovery from Ischemic Stress Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2016 | Pubmed ID: 26661187 Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model International Journal of Radiation Oncology, Biology, Physics. Nov, 2015 | Pubmed ID: 26530759 CB1 Cannabinoid Receptor Agonist Inhibits Matrix Metalloproteinase Activity in Spinal Cord Injury: A Possible Mechanism of Improved Recovery Neuroscience Letters. Jun, 2015 | Pubmed ID: 25881484 Sustained Functional Improvement by Hepatocyte Growth Factor-like Small Molecule BB3 After Focal Cerebral Ischemia in Rats and Mice Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jun, 2015 | Pubmed ID: 25712497 A Blinded Randomized Assessment of Laser Doppler Flowmetry Efficacy in Standardizing Outcome from Intraluminal Filament MCAO in the Rat Journal of Neuroscience Methods. Feb, 2015 | Pubmed ID: 25526908 Neuron-specific Sumo1-3 Knockdown in Mice Impairs Episodic and Fear Memories Journal of Psychiatry & Neuroscience : JPN. Jul, 2014 | Pubmed ID: 24690371 ApoE Mimetic Ameliorates Motor Deficit and Tissue Damage in Rat Spinal Cord Injury Journal of Neuroscience Research. Jul, 2014 | Pubmed ID: 24633884 Small Ubiquitin-like Modifier 3-modified Proteome Regulated by Brain Ischemia in Novel Small Ubiquitin-like Modifier Transgenic Mice: Putative Protective Proteins/pathways Stroke; a Journal of Cerebral Circulation. Apr, 2014 | Pubmed ID: 24569813 Characterization of the Ubiquitin-modified Proteome Regulated by Transient Forebrain Ischemia Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2014 | Pubmed ID: 24301296 Metalloporphyrins As Therapeutic Catalytic Oxidoreductants in Central Nervous System Disorders Antioxidants & Redox Signaling. May, 2014 | Pubmed ID: 23706004 Differential Coordination Demands in Fe Versus Mn Water-soluble Cationic Metalloporphyrins Translate into Remarkably Different Aqueous Redox Chemistry and Biology Inorganic Chemistry. May, 2013 | Pubmed ID: 23646875 Protective Astrogenesis from the SVZ Niche After Injury is Controlled by Notch Modulator Thbs4 Nature. May, 2013 | Pubmed ID: 23615612 Comprehensive Pharmacokinetic Studies and Oral Bioavailability of Two Mn Porphyrin-based SOD Mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+ Free Radical Biology & Medicine. May, 2013 | Pubmed ID: 23328731 Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-based Redox Modulators Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre. 2013 | Pubmed ID: 23075911 Lack of Evidence for a Remote Effect of Renal Ischemia/reperfusion Acute Kidney Injury on Outcome from Temporary Focal Cerebral Ischemia in the Rat Journal of Cardiothoracic and Vascular Anesthesia. Feb, 2013 | Pubmed ID: 22841525 Xenon Neuroprotection in Experimental Stroke: Interactions with Hypothermia and Intracerebral Hemorrhage Anesthesiology. Dec, 2012 | Pubmed ID: 23143806 A New SOD Mimic, Mn(III) Ortho N-butoxyethylpyridylporphyrin, Combines Superb Potency and Lipophilicity with Low Toxicity Free Radical Biology & Medicine. May, 2012 | Pubmed ID: 22336516 Analysis of Oxygen/glucose-deprivation-induced Changes in SUMO3 Conjugation Using SILAC-based Quantitative Proteomics Journal of Proteome Research. Feb, 2012 | Pubmed ID: 22082260 Neuroprotective Efficacy from a Lipophilic Redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage The Journal of Pharmacology and Experimental Therapeutics. Sep, 2011 | Pubmed ID: 21652782 Methoxy-derivatization of Alkyl Chains Increases the in Vivo Efficacy of Cationic Mn Porphyrins. Synthesis, Characterization, SOD-like Activity, and SOD-deficient E. Coli Study of Meta Mn(III) N-methoxyalkylpyridylporphyrins Dalton Transactions (Cambridge, England : 2003). Apr, 2011 | Pubmed ID: 21384047 The Effect of Blood Pressure on Cerebral Outcome in a Rat Model of Cerebral Air Embolism During Cardiopulmonary Bypass The Journal of Thoracic and Cardiovascular Surgery. Aug, 2011 | Pubmed ID: 21277590 Pharmacologically Augmented S-nitrosylated Hemoglobin Improves Recovery from Murine Subarachnoid Hemorrhage Stroke; a Journal of Cerebral Circulation. Feb, 2011 | Pubmed ID: 21193749 Aprotinin Improves Functional Outcome but Not Cerebral Infarct Size in an Experimental Model of Stroke During Cardiopulmonary Bypass Anesthesia and Analgesia. Jul, 2010 | Pubmed ID: 20519424 Development of a Simplified Spinal Cord Ischemia Model in Mice Journal of Neuroscience Methods. Jun, 2010 | Pubmed ID: 20394775 Simvastatin Treatment Duration and Cognitive Preservation in Experimental Subarachnoid Hemorrhage Journal of Neurosurgical Anesthesiology. Oct, 2009 | Pubmed ID: 19955895 Long-term Neuroprotection from a Potent Redox-modulating Metalloporphyrin in the Rat Free Radical Biology & Medicine. Oct, 2009 | Pubmed ID: 19631268 Long-term Cognitive Dysfunction Following Experimental Subarachnoid Hemorrhage: New Perspectives Experimental Neurology. Oct, 2008 | Pubmed ID: 18625221 Cerebral Ischemia/stroke and Small Ubiquitin-like Modifier (SUMO) Conjugation--a New Target for Therapeutic Intervention? Journal of Neurochemistry. Aug, 2008 | Pubmed ID: 18410505 Transient Focal Cerebral Ischemia Induces a Dramatic Activation of Small Ubiquitin-like Modifier Conjugation Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2008 | Pubmed ID: 18167501 Transient Global Cerebral Ischemia Induces a Massive Increase in Protein Sumoylation Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2008 | Pubmed ID: 17565359 Superparamagnetic Iron Oxide Labeling and Transplantation of Adipose-derived Stem Cells in Middle Cerebral Artery Occlusion-injured Mice AJR. American Journal of Roentgenology. Apr, 2007 | Pubmed ID: 17377054 Isoflurane Provides Long-term Protection Against Focal Cerebral Ischemia in the Rat Anesthesiology. Jan, 2007 | Pubmed ID: 17197850 Levetiracetam is Neuroprotective in Murine Models of Closed Head Injury and Subarachnoid Hemorrhage Neurocritical Care. 2006 | Pubmed ID: 16960300 Selective Gamma-aminobutyric Acid Type A Receptor Antagonism Reverses Isoflurane Ischemic Neuroprotection Anesthesiology. Jul, 2006 | Pubmed ID: 16809998 A Novel ApoE-derived Therapeutic Reduces Vasospasm and Improves Outcome in a Murine Model of Subarachnoid Hemorrhage Neurocritical Care. 2006 | Pubmed ID: 16498192 A Comparison of Hyperbaric Oxygen Versus Hypoxic Cerebral Preconditioning in Neonatal Rats Brain Research. Feb, 2006 | Pubmed ID: 16458861 Effects of a Manganese (III) Porphyrin Catalytic Antioxidant in a Mouse Closed Head Injury Model European Journal of Pharmacology. Feb, 2006 | Pubmed ID: 16455070 Intraischemic Nitrous Oxide Alters Neither Neurologic nor Histologic Outcome: a Comparison with Dizocilpine Anesthesia and Analgesia. Sep, 2004 | Pubmed ID: 15333428 Oxidants, Antioxidants and the Ischemic Brain The Journal of Experimental Biology. Aug, 2004 | Pubmed ID: 15299043 Mouse Spinal Cord Compression Injury is Ameliorated by Intrathecal Cationic Manganese(III) Porphyrin Catalytic Antioxidant Therapy Neuroscience Letters. Aug, 2004 | Pubmed ID: 15276251 A No-laminectomy Spinal Cord Compression Injury Model in Mice Journal of Neurotrauma. May, 2004 | Pubmed ID: 15165367 Effects of Isoflurane Versus Fentanyl-nitrous Oxide Anesthesia on Long-term Outcome from Severe Forebrain Ischemia in the Rat Anesthesiology. May, 2004 | Pubmed ID: 15114213 Severe Hypotension is Not Essential for Isoflurane Neuroprotection Against Forebrain Ischemia in Mice Anesthesiology. Nov, 2003 | Pubmed ID: 14576552 Possible Role for Vascular Cell Proliferation in Cerebral Vasospasm After Subarachnoid Hemorrhage Stroke; a Journal of Cerebral Circulation. Feb, 2003 | Pubmed ID: 12574555 Catalytic Antioxidants As Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury Drug News & Perspectives. Dec, 2002 | Pubmed ID: 12677251 Hemodynamic Effects of Metalloporphyrin Catalytic Antioxidants: Structure-activity Relationships and Species Specificity Free Radical Biology & Medicine. Dec, 2002 | Pubmed ID: 12488134 Simvastatin Increases Endothelial Nitric Oxide Synthase and Ameliorates Cerebral Vasospasm Resulting from Subarachnoid Hemorrhage Stroke; a Journal of Cerebral Circulation. Dec, 2002 | Pubmed ID: 12468796 A Catalytic Antioxidant (AEOL 10150) Attenuates Expression of Inflammatory Genes in Stroke Free Radical Biology & Medicine. Oct, 2002 | Pubmed ID: 12374626 Effects of Metalloporphyrin Catalytic Antioxidants in Experimental Brain Ischemia Free Radical Biology & Medicine. Oct, 2002 | Pubmed ID: 12361805 Attenuation of Cerebral Vasospasm After Subarachnoid Hemorrhage in Mice Overexpressing Extracellular Superoxide Dismutase Stroke; a Journal of Cerebral Circulation. Sep, 2002 | Pubmed ID: 12215605 Mouse Model of Subarachnoid Hemorrhage Associated Cerebral Vasospasm: Methodological Analysis Neurological Research. Jul, 2002 | Pubmed ID: 12117325 Pharmacological Correction of Hypothermic P(50) Shift Does Not Alter Outcome from Focal Cerebral Ischemia in Rats American Journal of Physiology. Heart and Circulatory Physiology. May, 2002 | Pubmed ID: 11959653 Neuroprotection from Delayed Postischemic Administration of a Metalloporphyrin Catalytic Antioxidant The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2001 | Pubmed ID: 11425886 Author Spotlight: Innovative Techniques and Future Directions in Stroke Research Huaxin Sheng1, Lihong Dang1, Xuan Li1, Zhong Yang1, Wei Yang1 1Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center JoVE 65345 Neuroscienze Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest Ran Li1, Weina Duan1, Dong Zhang2, Ulrike Hoffmann3, Junjie Yao2, Wei Yang1, Huaxin Sheng1 1Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center, 2Department of Biomedical Engineering, Duke University, 3Department of Anesthesiology and Pain Management, UT Southwestern University Medical Center JoVE 65340 Neuroscienze Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage Beilei Lei1, Huaxin Sheng1, Haichen Wang2, Christopher D. Lascola3, David S. Warner1,4, Daniel T. Laskowitz1,2,4, Michael L. James1,2 1Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, 2Department of Neurology, Duke University, 3Department of Radiology, Duke University, 4Department of Neurobiology, Duke University JoVE 51439 Medicina
Author Spotlight: Innovative Techniques and Future Directions in Stroke Research Huaxin Sheng1, Lihong Dang1, Xuan Li1, Zhong Yang1, Wei Yang1 1Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center JoVE 65345 Neuroscienze
Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest Ran Li1, Weina Duan1, Dong Zhang2, Ulrike Hoffmann3, Junjie Yao2, Wei Yang1, Huaxin Sheng1 1Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center, 2Department of Biomedical Engineering, Duke University, 3Department of Anesthesiology and Pain Management, UT Southwestern University Medical Center JoVE 65340 Neuroscienze
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage Beilei Lei1, Huaxin Sheng1, Haichen Wang2, Christopher D. Lascola3, David S. Warner1,4, Daniel T. Laskowitz1,2,4, Michael L. James1,2 1Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, 2Department of Neurology, Duke University, 3Department of Radiology, Duke University, 4Department of Neurobiology, Duke University JoVE 51439 Medicina
