Philip R. LeDuc Department of Mechanical Engineering Carnegie Mellon University Biography Publications Institution JoVE Articles Philip R. LeDuc has not added a biography. If you are Philip R. LeDuc and would like to personalize this page please email our Author Liaison for assistance. Publications Inducing Vascular Grammars for Anomaly Classification in Brain Angiograms Journal of Engineering and Science in Medical Diagnostics and Therapy. May, 2022 | Pubmed ID: 35833206 Freeform 3D Ice Printing (3D-ICE) at the Micro Scale Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Sep, 2022 | Pubmed ID: 35794454 Microfluidics for Understanding Model Organisms Nature Communications. Jun, 2022 | Pubmed ID: 35680898 Cell Alignment Modulated by Surface Nano-topography - Roles of Cell-matrix and Cell-cell Interactions Acta Biomaterialia. Apr, 2022 | Pubmed ID: 35124266 Toward Sustainable Desalination Using Food Waste: Capacitive Desalination with Bread-derived Electrodes RSC Advances. Mar, 2021 | Pubmed ID: 35423429 3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening Molecular Cancer Therapeutics. Jun, 2021 | Pubmed ID: 33785649 Hierarchical Machine Learning for High-Fidelity 3D Printed Biopolymers ACS Biomaterials Science & Engineering. Dec, 2020 | Pubmed ID: 33320614 Probing Coordinated Co-culture Cancer Related Motility Through Differential Micro-compartmentalized Elastic Substrates Scientific Reports. Oct, 2020 | Pubmed ID: 33116169 Toward Vasculature in Skeletal Muscle-on-a-Chip Through Thermo-Responsive Sacrificial Templates Micromachines. Sep, 2020 | Pubmed ID: 33007890 3D In Vitro Neuron on a Chip for Probing Calcium Mechanostimulation Advanced Biosystems. Oct, 2020 | Pubmed ID: 32875741 Decidual Vasculopathy Identification in Whole Slide Images Using Multiresolution Hierarchical Convolutional Neural Networks The American Journal of Pathology. Oct, 2020 | Pubmed ID: 32679230 Chemotactic Responses of Jurkat Cells in Microfluidic Flow-Free Gradient Chambers Micromachines. Apr, 2020 | Pubmed ID: 32260431 Polycarbonate Heat Molding for Soft Lithography Small (Weinheim an Der Bergstrasse, Germany). Apr, 2020 | Pubmed ID: 32227442 Tumor-on-a-chip for Integrating a 3D Tumor Microenvironment: Chemical and Mechanical Factors Lab on a Chip. Mar, 2020 | Pubmed ID: 32025687 A Biosensing Soft Robot: Autonomous Parsing of Chemical Signals Through Integrated Organic and Inorganic Interfaces Science Robotics. Jun, 2019 | Pubmed ID: 33137770 Author Correction: Mimicking Embedded Vasculature Structure for 3D Cancer on a Chip Approaches Through Micromilling Scientific Reports. Mar, 2019 | Pubmed ID: 30918272 High-throughput Mechanotransduction in Drosophila Embryos with Mesofluidics Lab on a Chip. Mar, 2019 | Pubmed ID: 30778467 Mimicking Embedded Vasculature Structure for 3D Cancer on a Chip Approaches Through Micromilling Scientific Reports. Dec, 2017 | Pubmed ID: 29196753 Robust Mechanobiological Behavior Emerges in Heterogeneous Myosin Systems Proceedings of the National Academy of Sciences of the United States of America. 09, 2017 | Pubmed ID: 28900011 How Can We Predict Cellular Mechanosensation?: Comment on "Cellular Mechanosensing of the Biophysical Microenvironment: A Review of Mathematical Models of Biophysical Regulation of Cell Responses" by Bo Cheng Et Al Physics of Life Reviews. 12, 2017 | Pubmed ID: 28890169 Biomimetic Scaffolds with Three-dimensional Undulated Microtopographies Biomaterials. Jun, 2017 | Pubmed ID: 28325683 2D and 3D Mechanobiology in Human and Nonhuman Systems ACS Applied Materials & Interfaces. Aug, 2016 | Pubmed ID: 27214883 Material Gradients in Stretchable Substrates Toward Integrated Electronic Functionality Advanced Materials (Deerfield Beach, Fla.). May, 2016 | Pubmed ID: 26989814 Geometric Effects in Microfluidics on Heterogeneous Cell Stress Using an Eulerian-Lagrangian Approach Lab on a Chip. Feb, 2016 | Pubmed ID: 26753780 The Role of Mechanics in Biological and Bio-inspired Systems Nature Communications. Jul, 2015 | Pubmed ID: 26145480 3D Bio-etching of a Complex Composite-like Embryonic Tissue Lab on a Chip. Aug, 2015 | Pubmed ID: 26138309 Controlled Surface Topography Regulates Collective 3D Migration by Epithelial-mesenchymal Composite Embryonic Tissues Biomaterials. Jul, 2015 | Pubmed ID: 25933063 Structurally Governed Cell Mechanotransduction Through Multiscale Modeling Scientific Reports. Feb, 2015 | Pubmed ID: 25722249 Cellular Force Signal Integration Through Vector Logic Gates Journal of Biomechanics. Feb, 2015 | Pubmed ID: 25614090 Sudden Motility Reversal Indicates Sensing of Magnetic Field Gradients in Magnetospirillum Magneticum AMB-1 Strain The ISME Journal. Jun, 2015 | Pubmed ID: 25478682 Beyond Disease, How Biomedical Engineering Can Improve Global Health Science Translational Medicine. Dec, 2014 | Pubmed ID: 25504880 Mechanochemical Actuators of Embryonic Epithelial Contractility Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25246549 Controlling Magnetotactic Bacteria Through an Integrated Nanofabricated Metallic Island and Optical Microscope Approach Scientific Reports. Feb, 2014 | Pubmed ID: 24553101 Biological Colloid Engineering: Self-assembly of Dipolar Ferromagnetic Chains in a Functionalized Biogenic Ferrofluid Applied Physics Letters. Aug, 2012 | Pubmed ID: 22952408 Frontiers of Optofluidics in Synthetic Biology Lab on a Chip. Oct, 2012 | Pubmed ID: 22895798 Calcium Signaling is Gated by a Mechanical Threshold in Three-dimensional Environments Scientific Reports. 2012 | Pubmed ID: 22870383 Cells Gain Traction in 3D Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22778421 Three-dimensional Microfiber Devices That Mimic Physiological Environments to Probe Cell Mechanics and Signaling Lab on a Chip. Apr, 2012 | Pubmed ID: 22374375 Mechanical Loading of Stem Cells for Improvement of Transplantation Outcome: The Role of Loading History Tissue Engineering. Part A. Jan, 2012 | Pubmed ID: 22280442 Three-dimensional Stochastic Off-lattice Model of Binding Chemistry in Crowded Environments PloS One. 2012 | Pubmed ID: 22272286 Mechanical Stretch and Shear Flow Induced Reorganization and Recruitment of Fibronectin in Fibroblasts Scientific Reports. 2011 | Pubmed ID: 22355663 Unified Regression Model of Binding Equilibria in Crowded Environments Scientific Reports. 2011 | Pubmed ID: 22355615 Investigating Circular Dorsal Ruffles Through Varying Substrate Stiffness and Mathematical Modeling Biophysical Journal. Nov, 2011 | Pubmed ID: 22067149 Bioinspirations: Cell-inspired Small-scale Systems for Enabling Studies in Experimental Biomechanics Integrative and Comparative Biology. Jul, 2011 | Pubmed ID: 21705801 How Do Control-based Approaches Enter into Biology? Annual Review of Biomedical Engineering. Aug, 2011 | Pubmed ID: 21599491 Dynamic Control of 3D Chemical Profiles with a Single 2D Microfluidic Platform Lab on a Chip. Jul, 2011 | Pubmed ID: 21528131 Microbial Electricity Generation Via Microfluidic Flow Control Biotechnology and Bioengineering. Sep, 2011 | Pubmed ID: 21495007 Fabrication of Circular Microfluidic Channels by Combining Mechanical Micromilling and Soft Lithography Lab on a Chip. Apr, 2011 | Pubmed ID: 21399830 Detection of Dynamic Spatiotemporal Response to Periodic Chemical Stimulation in a Xenopus Embryonic Tissue PloS One. 2011 | Pubmed ID: 21305055 Response of an Actin Filament Network Model Under Cyclic Stretching Through a Coarse Grained Monte Carlo Approach Journal of Theoretical Biology. Apr, 2011 | Pubmed ID: 21241710 Localized Bimodal Response of Neurite Extensions and Structural Proteins in Dorsal-root Ganglion Neurons with Controlled Polydimethylsiloxane Substrate Stiffness Journal of Biomechanics. Mar, 2011 | Pubmed ID: 21208617 Probing Localized Neural Mechanotransduction Through Surface-modified Elastomeric Matrices and Electrophysiology Nature Protocols. Apr, 2010 | Pubmed ID: 20360766 Three-dimensional Chemical Profile Manipulation Using Two-dimensional Autonomous Microfluidic Control Journal of the American Chemical Society. Feb, 2010 | Pubmed ID: 20063880 Probing Cell Structure Responses Through a Shear and Stretching Mechanical Stimulation Technique Cell Biochemistry and Biophysics. Apr, 2010 | Pubmed ID: 20033625 Defining the Role of Syndecan-4 in Mechanotransduction Using Surface-modification Approaches Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 20080785 Parameter Effects on Binding Chemistry in Crowded Media Using a Two-dimensional Stochastic Off-lattice Model Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Oct, 2009 | Pubmed ID: 19905353 Fabricating Small-scale, Curved, Polymeric Structures with Convex and Concave Menisci Through Interfacial Free Energy Equilibrium Lab on a Chip. Nov, 2009 | Pubmed ID: 19865741 Modulation of Fluidic Resistance and Capacitance for Long-term, High-speed Feedback Control of a Microfluidic Interface Lab on a Chip. Sep, 2009 | Pubmed ID: 19680585 Dynamics of Individual Polymers Using Microfluidic Based Microcurvilinear Flow Lab on a Chip. Aug, 2009 | Pubmed ID: 19636465 Spatiotemporal Control of Apical and Basal Living Subcellular Chemical Environments Through Vertical Phase Separation Small (Weinheim an Der Bergstrasse, Germany). Sep, 2009 | Pubmed ID: 19548276 Composite Polymer Systems with Control of Local Substrate Elasticity and Their Effect on Cytoskeletal and Morphological Characteristics of Adherent Cells Biomaterials. Jun, 2009 | Pubmed ID: 19299009 Probing Cellular Dynamics with a Chemical Signal Generator PloS One. 2009 | Pubmed ID: 19287482 Understanding Sensory Nerve Mechanotransduction Through Localized Elastomeric Matrix Control PloS One. 2009 | Pubmed ID: 19173000 Probing Cell Structure by Controlling the Mechanical Environment with Cell-substrate Interactions Journal of Biomechanics. Jan, 2009 | Pubmed ID: 19064266 Structure and Dynamics of Single DNA Molecules Manipulated by Magnetic Tweezers and or Flow Methods (San Diego, Calif.). Mar, 2009 | Pubmed ID: 19015032 Stochastic Off-lattice Modeling of Molecular Self-assembly in Crowded Environments by Green's Function Reaction Dynamics Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Sep, 2008 | Pubmed ID: 18851069 Spatiotemporal Response of Living Cell Structures in Dictyostelium Discoideum with Semiconductor Quantum Dots Nano Letters. May, 2008 | Pubmed ID: 18386936 Artificial Cells: Building Bioinspired Systems Using Small-scale Biology Trends in Biotechnology. Jan, 2008 | Pubmed ID: 18037179 Towards an in Vivo Biologically Inspired Nanofactory Nature Nanotechnology. Jan, 2007 | Pubmed ID: 18654192 Computational Models of Molecular Self-organization in Cellular Environments Cell Biochemistry and Biophysics. 2007 | Pubmed ID: 17703065 Creating Ordered Small-scale Biologically-based Rods Through Force-controlled Stamping Journal of the American Chemical Society. Aug, 2007 | Pubmed ID: 17636910 Chemically Encapsulated Structural Elements for Probing the Mechanical Responses of Biologically Inspired Systems Langmuir : the ACS Journal of Surfaces and Colloids. Jul, 2007 | Pubmed ID: 17585787 Pressure-driven Spatiotemporal Control of the Laminar Flow Interface in a Microfluidic Network Lab on a Chip. May, 2007 | Pubmed ID: 17476388 Force-controlled Inorganic Crystallization Lithography Journal of the American Chemical Society. Sep, 2006 | Pubmed ID: 16967953 Three-dimensional Molecular Phase Separation and Flow Patterns with Novel Multilevel Fluidics Molecular & Cellular Biomechanics : MCB. Jun, 2006 | Pubmed ID: 16903258 Micropatterning Polyvinyl Alcohol As a Biomimetic Material Through Soft Lithography with Cell Culture Molecular BioSystems. Jun, 2006 | Pubmed ID: 16880948 Evaluating Spatial Constraints in Cellular Assembly Processes Using a Monte Carlo Approach Cell Biochemistry and Biophysics. 2006 | Pubmed ID: 16757820 Understanding Actin Organization in Cell Structure Through Lattice Based Monte Carlo Simulations Mechanics & Chemistry of Biosystems : MCB. Jun, 2004 | Pubmed ID: 16783938 Integrated Lithographic Membranes and Surface Adhesion Chemistry for Three-dimensional Cellular Stimulation Langmuir : the ACS Journal of Surfaces and Colloids. Dec, 2004 | Pubmed ID: 15595783 Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System Utku M. Sönmez1, Nolan Frey2, Jonathan S. Minden2, Philip R. LeDuc1 1Department of Mechanical Engineering, Carnegie Mellon University, 2Department of Biological Sciences, Carnegie Mellon University JoVE 64281 Bioingegneria
Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System Utku M. Sönmez1, Nolan Frey2, Jonathan S. Minden2, Philip R. LeDuc1 1Department of Mechanical Engineering, Carnegie Mellon University, 2Department of Biological Sciences, Carnegie Mellon University JoVE 64281 Bioingegneria
