Thijn R. Brummelkamp

Publications

• Actin Maturation Requires the ACTMAP/C19orf54 Protease
  Science (New York, N.Y.). Sep, 2022  |   Pubmed ID: 36173861
• The Cohesin Acetylation Cycle Controls Chromatin Loop Length Through a PDS5A Brake Mechanism
  Nature Structural & Molecular Biology. Jun, 2022  |   Pubmed ID: 35710836
• Posttranslational Modification of Microtubules by the MATCAP Detyrosinase
  Science (New York, N.Y.). May, 2022  |   Pubmed ID: 35482892
• A Mediator-cohesin Axis Controls Heterochromatin Domain Formation
  Nature Communications. Feb, 2022  |   Pubmed ID: 35136067
• E3 Ubiquitin Ligase Mindbomb 1 Facilitates Nuclear Delivery of Adenovirus Genomes
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2021  |   Pubmed ID: 33443154
• The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses
  Immunity. Jan, 2021  |   Pubmed ID: 33271119
• Quantitative Genetic Screening Reveals a Ragulator-FLCN Feedback Loop That Regulates the MTORC1 Pathway
  Science Signaling. Sep, 2020  |   Pubmed ID: 32934076
• Regulates the Action of Nitrogen-containing Bisphosphonates on Bone
  Science Translational Medicine. May, 2020  |   Pubmed ID: 32434850
• Haploid Genetic Screens Identify SPRING/C12ORF49 As a Determinant of SREBP Signaling and Cholesterol Metabolism
  Nature Communications. Feb, 2020  |   Pubmed ID: 32111832
• A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 As Factors Supporting Vaccinia Virus Infection
  Journal of Virology. Jul, 2019  |   Pubmed ID: 30996093
• Glutaminyl Cyclase is an Enzymatic Modifier of the CD47- SIRPα Axis and a Target for Cancer Immunotherapy
  Nature Medicine. Apr, 2019  |   Pubmed ID: 30833751
• SLFN11 Can Sensitize Tumor Cells Towards IFN-γ-mediated T Cell Killing
  PloS One. 2019  |   Pubmed ID: 30753225
• BRCA2 Deficiency Instigates CGAS-mediated Inflammatory Signaling and Confers Sensitivity to Tumor Necrosis Factor-alpha-mediated Cytotoxicity
  Nature Communications. Jan, 2019  |   Pubmed ID: 30626869
• The Tubulin Detyrosination Cycle: Function and Enzymes
  Trends in Cell Biology. Jan, 2019  |   Pubmed ID: 30213517
• Protocadherin-1 is Essential for Cell Entry by New World Hantaviruses
  Nature. 11, 2018  |   Pubmed ID: 30464266
• LZTR1 is a Regulator of RAS Ubiquitination and Signaling
  Science (New York, N.Y.). Dec, 2018  |   Pubmed ID: 30442766
• Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma
  Cancer Research. Dec, 2018  |   Pubmed ID: 30213788
• Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores
  Current Biology : CB. Sep, 2018  |   Pubmed ID: 30122526
• Viral Escape from Endosomes and Host Detection at a Glance
  Journal of Cell Science. Aug, 2018  |   Pubmed ID: 30076240
• Haploid Genetic Screens Identify Genetic Vulnerabilities to Microtubule-targeting Agents
  Molecular Oncology. Jun, 2018  |   Pubmed ID: 29689640
• KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses
  Cell Host & Microbe. May, 2018  |   Pubmed ID: 29681460
• BUB1 Is Essential for the Viability of Human Cells in Which the Spindle Assembly Checkpoint Is Compromised
  Cell Reports. Feb, 2018  |   Pubmed ID: 29425499
• NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry
  Cell Host & Microbe. Nov, 2017  |   Pubmed ID: 29120745
• Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread
  Cell Host & Microbe. Oct, 2017  |   Pubmed ID: 29024641
• Identification of CMTM6 and CMTM4 As PD-L1 Protein Regulators
  Nature. Sep, 2017  |   Pubmed ID: 28813410
• Genetic Wiring Maps of Single-cell Protein States Reveal an Off-switch for GPCR Signalling
  Nature. Jun, 2017  |   Pubmed ID: 28562590
• The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
  Cell. May, 2017  |   Pubmed ID: 28475897
• A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles
  MSphere. 2016  |   Pubmed ID: 27303731
• Enterovirus D68 Receptor Requirements Unveiled by Haploid Genetics
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016  |   Pubmed ID: 26787879
• A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection
  Journal of Virology. Feb, 2016  |   Pubmed ID: 26581979
• Filovirus Receptor NPC1 Contributes to Species-specific Patterns of Ebolavirus Susceptibility in Bats
  ELife. 2015  |   Pubmed ID: 26698106
• Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation
  Chemistry & Biology. Dec, 2015  |   Pubmed ID: 26687144
• A Generic Strategy for CRISPR-Cas9-mediated Gene Tagging
  Nature Communications. Dec, 2015  |   Pubmed ID: 26674669
• Subunit Composition of VRAC Channels Determines Substrate Specificity and Cellular Resistance to Pt-based Anti-cancer Drugs
  The EMBO Journal. Dec, 2015  |   Pubmed ID: 26530471
• Gene Essentiality and Synthetic Lethality in Haploid Human Cells
  Science (New York, N.Y.). Nov, 2015  |   Pubmed ID: 26472760
• Compromising the 19S Proteasome Complex Protects Cells from Reduced Flux Through the Proteasome
  ELife. Sep, 2015  |   Pubmed ID: 26327695
• Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer
  Cancer Research. Oct, 2015  |   Pubmed ID: 26260527
• Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion
  MBio. Jun, 2015  |   Pubmed ID: 26126854
• GENE REGULATION. A HUSH for Transgene Expression
  Science (New York, N.Y.). Jun, 2015  |   Pubmed ID: 26113708
• Niemann-pick C1 is Essential for Ebolavirus Replication and Pathogenesis in Vivo
  MBio. May, 2015  |   Pubmed ID: 26015498
• Emerging Intracellular Receptors for Hemorrhagic Fever Viruses
  Trends in Microbiology. Jul, 2015  |   Pubmed ID: 26004032
• Megabase-scale Deletion Using CRISPR/Cas9 to Generate a Fully Haploid Human Cell Line
  Genome Research. Dec, 2014  |   Pubmed ID: 25373145
• The Solute Carrier SLC35F2 Enables YM155-mediated DNA Damage Toxicity
  Nature Chemical Biology. Sep, 2014  |   Pubmed ID: 25064833
• GPR107, a G-protein-coupled Receptor Essential for Intoxication by Pseudomonas Aeruginosa Exotoxin A, Localizes to the Golgi and is Cleaved by Furin
  The Journal of Biological Chemistry. Aug, 2014  |   Pubmed ID: 25031321
• USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen
  Cancer Research. Jul, 2014  |   Pubmed ID: 25028367
• Virus Entry. Lassa Virus Entry Requires a Trigger-induced Receptor Switch
  Science (New York, N.Y.). Jun, 2014  |   Pubmed ID: 24970085
• Caspase-mediated Cleavage of Phospholipid Flippase for Apoptotic Phosphatidylserine Exposure
  Science (New York, N.Y.). Jun, 2014  |   Pubmed ID: 24904167
• LRP1 is a Receptor for Clostridium Perfringens TpeL Toxin Indicating a Two-receptor Model of Clostridial Glycosylating Toxins
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014  |   Pubmed ID: 24737893
• Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells
  Cell Reports. Apr, 2014  |   Pubmed ID: 24685140
• A Reversible Gene Trap Collection Empowers Haploid Genetics in Human Cells
  Nature Methods. Oct, 2013  |   Pubmed ID: 24161985
• Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry
  Science (New York, N.Y.). Apr, 2013  |   Pubmed ID: 23519211
• Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T Helper Type 2)-associated Adjuvants
  The Journal of Biological Chemistry. Mar, 2013  |   Pubmed ID: 23297415
• Ebola Virus Entry Requires the Host-programmed Recognition of an Intracellular Receptor
  The EMBO Journal. Apr, 2012  |   Pubmed ID: 22395071
• Suppression of the P53-dependent Replicative Senescence Response by Lysophosphatidic Acid Signaling
  Molecular Cancer Research : MCR. Sep, 2008  |   Pubmed ID: 18723828
• ShRNA Libraries and Their Use in Cancer Genetics
  Nature Methods. Sep, 2006  |   Pubmed ID: 16929315
• An ShRNA Barcode Screen Provides Insight into Cancer Cell Vulnerability to MDM2 Inhibitors
  Nature Chemical Biology. Apr, 2006  |   Pubmed ID: 16474381
• A Genomic and Functional Inventory of Deubiquitinating Enzymes
  Cell. Dec, 2005  |   Pubmed ID: 16325574
• Functional Annotation of Deubiquitinating Enzymes Using RNA Interference
  Methods in Enzymology. 2005  |   Pubmed ID: 16275358
• The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway
  Molecular Cell. Feb, 2005  |   Pubmed ID: 15694335
• A Large-scale RNAi Screen in Human Cells Identifies New Components of the P53 Pathway
  Nature. Mar, 2004  |   Pubmed ID: 15042092
• Human Immunodeficiency Virus Type 1 Escapes from RNA Interference-mediated Inhibition
  Journal of Virology. Mar, 2004  |   Pubmed ID: 14963165
• New Tools for Functional Mammalian Cancer Genetics
  Nature Reviews. Cancer. Oct, 2003  |   Pubmed ID: 14570045
• Loss of the Cylindromatosis Tumour Suppressor Inhibits Apoptosis by Activating NF-kappaB
  Nature. Aug, 2003  |   Pubmed ID: 12917690
• Specific Inhibition of Gene Expression Using a Stably Integrated, Inducible Small-interfering-RNA Vector
  EMBO Reports. Jun, 2003  |   Pubmed ID: 12776180
• Stable Suppression of Tumorigenicity by Virus-mediated RNA Interference
  Cancer Cell. Sep, 2002  |   Pubmed ID: 12242156
• A Senescence Rescue Screen Identifies BCL6 As an Inhibitor of Anti-proliferative P19(ARF)-p53 Signaling
  Genes & Development. Mar, 2002  |   Pubmed ID: 11914273
• A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
  Science (New York, N.Y.). Apr, 2002  |   Pubmed ID: 11910072
• TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, is a Negative Regulator of P19ARF and Inhibits Senescence
  The Journal of Biological Chemistry. Feb, 2002  |   Pubmed ID: 11748239
• Crystal Structure of the Tubulin Tyrosine Carboxypeptidase Complex VASH1-SVBP
  Nature Structural & Molecular Biology.   |   Pubmed ID: 31270470
• Vasohibins Encode Tubulin Detyrosinating Activity
  Science (New York, N.Y.).   |   Pubmed ID: 29146869
• PLA2G16 Represents a Switch Between Entry and Clearance of Picornaviridae
  Nature.   |   Pubmed ID: 28077878