Yimon Aye Swiss Federal Institute of Technology Lausanne (EPFL) Biography Publications Institution JoVE Articles Yimon Aye has not added a biography. If you are Yimon Aye and would like to personalize this page please email our Author Liaison for assistance. Publications Z-REX: Shepherding Reactive Electrophiles to Specific Proteins Expressed Tissue Specifically or Ubiquitously, and Recording the Resultant Functional Electrophile-induced Redox Responses in Larval Fish Nature Protocols. May, 2023 | Pubmed ID: 37020146 Finding a Vocation for Validation: Taking Proteomics Beyond Association and Location RSC Chemical Biology. Feb, 2023 | Pubmed ID: 36794020 Still No Rest for the Reductases: Ribonucleotide Reductase (RNR) Structure and Function: An Update Sub-cellular Biochemistry. 2022 | Pubmed ID: 36151376 A Journey Through the Life of Professor David A. Evans ACS Chemical Biology. Aug, 2022 | Pubmed ID: 35852412 Hiding in Plain Sight: The Issue of Hidden Variables ACS Chemical Biology. Jun, 2022 | Pubmed ID: 35603432 Keap 1: The New Janus Word on the Block Bioorganic & Medicinal Chemistry Letters. Sep, 2022 | Pubmed ID: 35537607 Function-guided Proximity Mapping Unveils Electrophilic-metabolite Sensing by Proteins Not Present in Their Canonical Locales Proceedings of the National Academy of Sciences of the United States of America. Feb, 2022 | Pubmed ID: 35082156 Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design? Chembiochem : a European Journal of Chemical Biology. Apr, 2022 | Pubmed ID: 33826211 A Primer on Harnessing Non-enzymatic Post-translational Modifications for Drug Design RSC Medicinal Chemistry. Nov, 2021 | Pubmed ID: 34825181 The Not So Identical Twins: (dis)similarities Between Reactive Electrophile and Oxidant Sensing and Signaling Chemical Society Reviews. Nov, 2021 | Pubmed ID: 34779447 Wdr1 and Cofilin Are Necessary Mediators of Immune-cell-specific Apoptosis Triggered by Tecfidera Nature Communications. Sep, 2021 | Pubmed ID: 34593792 Science's Response to CoVID-19 ChemMedChem. Aug, 2021 | Pubmed ID: 33811458 An Oculus to Profile and Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution into G-REX Accounts of Chemical Research. Feb, 2021 | Pubmed ID: 33228351 Neighborhood Watch: Tools for Defining Locale-dependent Subproteomes and Their Contextual Signaling Activities RSC Chemical Biology. Jun, 2020 | Pubmed ID: 34458747 The MRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor Helvetica Chimica Acta. May, 2020 | Pubmed ID: 34113045 Where Electrophile Signaling and Covalent Ligand-Target Mining Converge Chimia. Sep, 2020 | Pubmed ID: 32958101 Precision Targeting of -Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing ACS Central Science. Jun, 2020 | Pubmed ID: 32607436 Empowering Global Chemical Biology at the Dawn of the New Decade ACS Chemical Biology. Jun, 2020 | Pubmed ID: 32315151 Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals Frontiers in Aging Neuroscience. 2020 | Pubmed ID: 32116644 REX Technologies for Profiling and Decoding the Electrophile Signaling Axes Mediated by Rosetta Stone Proteins Methods in Enzymology. 2020 | Pubmed ID: 32046846 Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis Cell Chemical Biology. Jan, 2020 | Pubmed ID: 31836351 The More the Merrier: How Homo-oligomerization Alters the Interactome and Function of Ribonucleotide Reductase Current Opinion in Chemical Biology. Feb, 2020 | Pubmed ID: 31734537 Getting the Right Grip? How Understanding Electrophile Selectivity Profiles Could Illuminate Our Understanding of Redox Signaling Antioxidants & Redox Signaling. Nov, 2020 | Pubmed ID: 31578876 Post-transcriptional Regulation of Nrf2-mRNA by the MRNA-binding Proteins HuR and AUF1 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2019 | Pubmed ID: 31665914 Editorial Overview: From the Iceman to Modern Medicine Current Opinion in Chemical Biology. Jun, 2019 | Pubmed ID: 31178257 Genie in a Bottle: Controlled Release Helps Tame Natural Polypharmacology? Current Opinion in Chemical Biology. Aug, 2019 | Pubmed ID: 30913473 Interrogating Precision Electrophile Signaling Trends in Biochemical Sciences. Apr, 2019 | Pubmed ID: 30765181 Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles Trends in Biochemical Sciences. Jan, 2019 | Pubmed ID: 30327250 Weighing Up the Selenocysteome Uncovers New Sec-rets Cell Chemical Biology. Nov, 2018 | Pubmed ID: 30445052 Nuclear RNR-α Antagonizes Cell Proliferation by Directly Inhibiting ZRANB3 Nature Chemical Biology. Oct, 2018 | Pubmed ID: 30150681 Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites Kuan-Ting Huang1, Phillippe Ly1, Jesse R. Poganik2, Saba Parvez3, Marcus J. C. Long4, Yimon Aye1 1Swiss Federal Institute of Technology Lausanne (EPFL), 2Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 3Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, 4University of Lausanne (UNIL) JoVE 64846 Biologia
Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites Kuan-Ting Huang1, Phillippe Ly1, Jesse R. Poganik2, Saba Parvez3, Marcus J. C. Long4, Yimon Aye1 1Swiss Federal Institute of Technology Lausanne (EPFL), 2Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 3Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, 4University of Lausanne (UNIL) JoVE 64846 Biologia
