Chapter 6
Protein Function
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their…
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most…
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein…
Enzymes are proteins made of amino acids. The functional group of each constituent amino acid catalyzes a wide variety of chemical reactions via…
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand…
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation,…
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as…
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an…
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s…
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical…
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major…
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other…
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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Proteins are an important class of biological macromolecules that play many key roles in cellular functions including gene expression, catalyzing…
Cells sense and respond to physical cues in their environment by converting mechanical stimuli into biochemically-detectable signals in a process…
Numerous intracellular proteins physically interact in accordance with their intracellular and extracellular circumstances. Indeed, cellular…
