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Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
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Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Article DOI: 10.3791/64514-v • 08:36 min • April 7th, 2023
April 7th, 2023 •
1, 1, 1, 1, 1
1Aneo Chem-Tech Co., Ltd

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Here, we present a protocol for the scaled-up synthesis of the intermediate tert-butyl (5-toluenesulfonyl-5h-pyrrole [2,3-b] pyrazine-2-yl) carbamate (ACT051-3) of Upatinib.

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Scaled-up Synthesis Intermediate Upatinib ACT051-3 Protocol Simple Low Cost Environmentally Friendly Compound 2-bromo-5-tosyl-5H-pyrrolo[2 3-b]pyrazine N,N-dimethylformamide DMF Diisopropylethylamine Nitrogen Protection Para-toluene Sulphonyl Chloride TsCl Water Bath Stirring Filtering Under Vacuum Pale Yellow Solid Yield Of 78% Synthesis 1,4-dioxane Tert-butyl Carbamate Granular Potassium Carbonate Xantphos Palladium Acetate Heating
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