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Genetics

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JoVE Journal Genetics
An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

A Comprehensive Approach to Studying the Promoter Interactome in Scarce Cells

Article DOI: 10.3791/65316-v • 01:54 min • April 21st, 2023
April 21st, 2023 •
*1, *1,2, 1, 2,3, 1,4
1Josep Carreras Leukaemia Research Institute, 2Barcelona Supercomputing Center, 3Catalan Institution for Research and Advanced Studies (ICREA), 4Institute for Health Science Research Germans Trias i Pujol
* These authors contributed equally

Tags

LiCHi-C Promoter-centric Spatio-temporal Genome Architecture Chromatin Interaction Gene Regulation Non-coding Mutation Disease Association Chromosomal Rearrangements 3D Chromatin Organization Scarce Cell Populations Primary Stem Cells Clinical Samples Protocol Input Materials Restriction Fragment Resolution Gene Expression Regulation Enhancers Silencers Target Gene Promoters
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