JoVE Journal

Cancer Research

JoVE Cancer Research illustrates experimental approaches in biomedical research and clinical practice aimed at understanding, detecting, treating and preventing cancer.

‹1 2 3 4 5 › 110 VIDEO ARTICLES

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Rui Xue Zhang¹, Tian Zhang¹, King Chen¹, Ji Cheng¹, Paris Lai¹, Andrew M. Rauth², K. Sandy Pang¹, Xiao Yu Wu¹

¹Department of Pharmaceutical Sciences, University of Toronto, ²Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute, University Health Network

JoVE 56159

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Erik S. Carlson^1,2, Pramod Upadhyaya², Stephen S. Hecht²

¹Department of Pharmacology, University of Minnesota, ²Masonic Cancer Center, University of Minnesota

JoVE 56312

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Laura Mercatali¹, Chiara Spadazzi¹, Giacomo Miserocchi¹, Chiara Liverani¹, Alessandro De Vita¹, Alberto Bongiovanni¹, Federica Recine¹, Dino Amadori¹, Toni Ibrahim¹

¹Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS

JoVE 56311

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Lisa Mohr¹, Marc Carceles-Cordon¹, Jungreem Woo¹, Carlos Cordon-Cardo¹, Josep Domingo-Domenech¹, Veronica Rodriguez-Bravo^1,2

¹Department of Pathology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, ²Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai

JoVE 56327

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

Nathaniel W Holton¹, Joel F Andrews¹, Natalie R Gassman¹

¹Department of Oncologic Sciences, University of South Alabama Mitchell Cancer Institute

JoVE 56265

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Xiaoxing Lv¹, Meiru Zhao¹, Yuting Yi¹, Lucheng Zhang¹, Yanfang Guan¹, Tao Liu¹, Ling Yang¹, Rongrong Chen¹, Jianhui Ma¹, Xin Yi¹

¹Geneplus-Beijing Institute

JoVE 56342

Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts

Pawan Noel¹, Ruben Muñoz¹, George W. Rogers², Andrew Neilson², Daniel D. Von Hoff¹, Haiyong Han¹

¹Molecular Medicine Division, Translational Genomics Research Institute, ²Agilent Technologies

JoVE 56081

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Toshimitsu Yamaoka¹, Motoi Ohba¹, Satoru Arata^1,2, Tohru Ohmori¹

¹Institute of Molecular Oncology, Showa University, ²Center for Biotechnology, Showa University

JoVE 55967

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Simone Punt¹, Robert J. Baatenburg de Jong², Ekaterina S. Jordanova^1,3

¹Department of Pathology, Leiden University Medical Center, ²Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus University Medical Center, ³Center for Gynecological Oncology Amsterdam, VU Medical Center

JoVE 55589

Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis

Charles E. Gast¹, Aubie K. Shaw^1,2, Melissa H. Wong^1,3, Lisa M. Coussens^1,3

¹Cell, Developmental & Cancer Biology, Oregon Health & Science University, ²University of Minnesota, ³Knight Cancer Institute, Oregon Health & Science University

JoVE 54852

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Kenta Morimoto^1,2, Yoichiro Tamori¹

¹Structural Biology Center, National Institute of Genetics and Department of Genetics, School of Life Science, SOKENDAI, ²Graduate School of Media and Governance, Keio University

JoVE 55901

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Deirdre K Tucker^1,2, Julie F Foley³, Schantel A Bouknight⁴, Suzanne E Fenton²

¹Curriculum in Toxicology, University of North Carolina at Chapel Hill, ²National Toxicology Program Laboratory (NTPL), DNTP, National Institute of Environmental Health Sciences, ³Cellular and Molecular Pathology Branch, DNTP, National Institute of Environmental Health Sciences, ⁴Charles River Laboratories Inc.

JoVE 55796

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Susan Kochall¹, May-Linn Thepkaysone¹, Sebastián A. García¹, Alexander M. Betzler¹, Jürgen Weitz^1,2,3, Christoph Reissfelder¹, Sebastian Schölch^1,2,3

¹Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, ²German Cancer Consortium (DKTK), ³German Cancer Research Center (DKFZ)

JoVE 55357

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Frank J. Jenkins^1,2, Charles M. Kerr², Elise Fouquerel^2,3, Dana H. Bovbjerg^2,4, Patricia L. Opresko^2,3

¹Departments of Pathology and Infectious Diseases and Microbiology, University of Pittsburgh, ²University of Pittsburgh Cancer Institute, ³Department of Environmental and Occupational Health, University of Pittsburgh, ⁴Departments of Psychiatry, Psychology, Behavioral & Community Health Sciences, University of Pittsburgh

JoVE 56001

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Alexander M. Betzler¹, Susan Kochall¹, Linda Blickensdörfer², Sebastian A. Garcia¹, May-Linn Thepkaysone¹, Lahiri K. Nanduri¹, Michael H. Muders³, Jürgen Weitz^1,4,5, Christoph Reissfelder¹, Sebastian Schölch^1,4,5

¹Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, ²Department of General, Gastrointestinal and Transplant Surgery, University of Heidelberg, ³Department of Pathology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, ⁴German Cancer Consortium (DKTK), ⁵German Cancer Research Center (DKFZ)

JoVE 55952

A Unified Methodological Framework for Vestibular Schwannoma Research

Lukas D. Landegger*^1,2,3, Jessica E. Sagers*^1,4, Sonam Dilwali^1,4, Takeshi Fujita^1,2, Mehmet I. Sahin^1,2, Konstantina M. Stankovic^1,2,4

¹Eaton Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear, ²Department of Otolaryngology, Harvard Medical School, ³Department of Otolaryngology, Vienna General Hospital, Medical University of Vienna, ⁴Program in Speech and Hearing Bioscience and Technology, Harvard Medical School

JoVE 55827

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Mattie J. Casey*¹, Katarzyna Modzelewska*¹, Daniela Anderson¹, James Goodman¹, Elena F. Boer¹, Laura Jimenez¹, Douglas Grossman^1,2, Rodney A. Stewart¹

¹Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, ²Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City

JoVE 55712

Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples

Maximilian Boesch*^1,2,3, Elisabeth Hoflehner^2,3, Dominik Wolf^2,3,4, Guenther Gastl², Sieghart Sopper*^2,3

¹Institute of Immunobiology, Kantonsspital St. Gallen, ²Internal Medicine V, Medical University of Innsbruck, ³Tyrolean Cancer Research Institute (TKFI), ⁴Medical Clinic III, Oncology, Hematology, Immunoncology and Rheumatology, University Clinic Bonn (UKB)

JoVE 55634

Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)

Yaara Porat¹, Moshe Giladi¹, Rosa S. Schneiderman¹, Roni Blat¹, Anna Shteingauz¹, Einav Zeevi¹, Mijal Munster¹, Tali Voloshin¹, Noa Kaynan¹, Orna Tal¹, Eilon D. Kirson², Uri Weinberg³, Yoram Palti²

¹Preclinical Research Department, Novocure Ltd., Haifa, Israel, ²Novocure Ltd., Haifa, Israel, ³Novocure GmbH, Lucerne, Switzerland

JoVE 55820

Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish

Jiang Ren*¹, Sijia Liu*¹, Chao Cui¹, Peter ten Dijke¹

¹Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center

JoVE 55459

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Katherine A. Murphy*^1,2, Britnie R. James*^1,2,3, Andrew Wilber^4,5, Thomas S. Griffith^1,2,3

¹Department of Urology, University of Minnesota, ²Masonic Cancer Center, University of Minnesota, ³Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, ⁴Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, ⁵Simmons Cancer Institute

JoVE 55080

In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues

József Murányi^1,2, Attila Varga¹, Bianka Gurbi¹, Pál Gyulavári¹, Gábor Mező³, Tibor Vántus²

¹MTA-SE Pathobiochemistry Research Group, Semmelweis University, ²Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, ³MTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd University

JoVE 55529

A Mouse Model of Fatigue Induced by Peripheral Irradiation

Brian S. Wolff¹, Michael A. Renner¹, Danielle A. Springer², Leorey N. Saligan¹

¹Symptom Biology Unit, National Institute of Nursing Research, National Institutes of Health, ²Murine Phenotyping Core, National Heart, Lung, and Blood Institute, National Institutes of Health

JoVE 55145

Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates

Viswanath Das¹, Tomáš Fürst¹, Soňa Gurská¹, Petr Džubák¹, Marián Hajdúch¹

¹Institute of Molecular and Translational Medicine, Palacky University in Olomouc

JoVE 55403

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