JoVE Journal

Cancer Research

JoVE Cancer Research includes experimental approaches and methods to understand, detect, treat, and prevent cancer.

‹1…3 4 5 6 › 127 VIDEO ARTICLES

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Toshimitsu Yamaoka¹, Motoi Ohba¹, Satoru Arata^1,2, Tohru Ohmori¹

¹Institute of Molecular Oncology, Showa University, ²Center for Biotechnology, Showa University

JoVE 55967

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Simone Punt¹, Robert J. Baatenburg de Jong², Ekaterina S. Jordanova^1,3

¹Department of Pathology, Leiden University Medical Center, ²Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus University Medical Center, ³Center for Gynecological Oncology Amsterdam, VU Medical Center

JoVE 55589

Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis

Charles E. Gast¹, Aubie K. Shaw^1,2, Melissa H. Wong^1,3, Lisa M. Coussens^1,3

¹Cell, Developmental & Cancer Biology, Oregon Health & Science University, ²University of Minnesota, ³Knight Cancer Institute, Oregon Health & Science University

JoVE 54852

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Kenta Morimoto^1,2, Yoichiro Tamori¹

¹Structural Biology Center, National Institute of Genetics and Department of Genetics, School of Life Science, SOKENDAI, ²Graduate School of Media and Governance, Keio University

JoVE 55901

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Deirdre K Tucker^1,2, Julie F Foley³, Schantel A Bouknight⁴, Suzanne E Fenton²

¹Curriculum in Toxicology, University of North Carolina at Chapel Hill, ²National Toxicology Program Laboratory (NTPL), DNTP, National Institute of Environmental Health Sciences, ³Cellular and Molecular Pathology Branch, DNTP, National Institute of Environmental Health Sciences, ⁴Charles River Laboratories Inc.

JoVE 55796

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Susan Kochall¹, May-Linn Thepkaysone¹, Sebastián A. García¹, Alexander M. Betzler¹, Jürgen Weitz^1,2,3, Christoph Reissfelder¹, Sebastian Schölch^1,2,3

¹Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, ²German Cancer Consortium (DKTK), ³German Cancer Research Center (DKFZ)

JoVE 55357

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Frank J. Jenkins^1,2, Charles M. Kerr², Elise Fouquerel^2,3, Dana H. Bovbjerg^2,4, Patricia L. Opresko^2,3

¹Departments of Pathology and Infectious Diseases and Microbiology, University of Pittsburgh, ²University of Pittsburgh Cancer Institute, ³Department of Environmental and Occupational Health, University of Pittsburgh, ⁴Departments of Psychiatry, Psychology, Behavioral & Community Health Sciences, University of Pittsburgh

JoVE 56001

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Alexander M. Betzler¹, Susan Kochall¹, Linda Blickensdörfer², Sebastian A. Garcia¹, May-Linn Thepkaysone¹, Lahiri K. Nanduri¹, Michael H. Muders³, Jürgen Weitz^1,4,5, Christoph Reissfelder¹, Sebastian Schölch^1,4,5

¹Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, ²Department of General, Gastrointestinal and Transplant Surgery, University of Heidelberg, ³Department of Pathology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, ⁴German Cancer Consortium (DKTK), ⁵German Cancer Research Center (DKFZ)

JoVE 55952

A Unified Methodological Framework for Vestibular Schwannoma Research

Lukas D. Landegger*^1,2,3, Jessica E. Sagers*^1,4, Sonam Dilwali^1,4, Takeshi Fujita^1,2, Mehmet I. Sahin^1,2, Konstantina M. Stankovic^1,2,4

¹Eaton Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear, ²Department of Otolaryngology, Harvard Medical School, ³Department of Otolaryngology, Vienna General Hospital, Medical University of Vienna, ⁴Program in Speech and Hearing Bioscience and Technology, Harvard Medical School

JoVE 55827

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Mattie J. Casey*¹, Katarzyna Modzelewska*¹, Daniela Anderson¹, James Goodman¹, Elena F. Boer¹, Laura Jimenez¹, Douglas Grossman^1,2, Rodney A. Stewart¹

¹Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, ²Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City

JoVE 55712

Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples

Maximilian Boesch*^1,2,3, Elisabeth Hoflehner^2,3, Dominik Wolf^2,3,4, Guenther Gastl², Sieghart Sopper*^2,3

¹Institute of Immunobiology, Kantonsspital St. Gallen, ²Internal Medicine V, Medical University of Innsbruck, ³Tyrolean Cancer Research Institute (TKFI), ⁴Medical Clinic III, Oncology, Hematology, Immunoncology and Rheumatology, University Clinic Bonn (UKB)

JoVE 55634

Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)

Yaara Porat¹, Moshe Giladi¹, Rosa S. Schneiderman¹, Roni Blat¹, Anna Shteingauz¹, Einav Zeevi¹, Mijal Munster¹, Tali Voloshin¹, Noa Kaynan¹, Orna Tal¹, Eilon D. Kirson², Uri Weinberg³, Yoram Palti²

¹Preclinical Research Department, Novocure Ltd., Haifa, Israel, ²Novocure Ltd., Haifa, Israel, ³Novocure GmbH, Lucerne, Switzerland

JoVE 55820

Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish

Jiang Ren*¹, Sijia Liu*¹, Chao Cui¹, Peter ten Dijke¹

¹Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center

JoVE 55459

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Katherine A. Murphy*^1,2, Britnie R. James*^1,2,3, Andrew Wilber^4,5, Thomas S. Griffith^1,2,3

¹Department of Urology, University of Minnesota, ²Masonic Cancer Center, University of Minnesota, ³Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, ⁴Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, ⁵Simmons Cancer Institute

JoVE 55080

In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues

József Murányi^1,2, Attila Varga¹, Bianka Gurbi¹, Pál Gyulavári¹, Gábor Mező³, Tibor Vántus²

¹MTA-SE Pathobiochemistry Research Group, Semmelweis University, ²Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, ³MTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd University

JoVE 55529

A Mouse Model of Fatigue Induced by Peripheral Irradiation

Brian S. Wolff¹, Michael A. Renner¹, Danielle A. Springer², Leorey N. Saligan¹

¹Symptom Biology Unit, National Institute of Nursing Research, National Institutes of Health, ²Murine Phenotyping Core, National Heart, Lung, and Blood Institute, National Institutes of Health

JoVE 55145

Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates

Viswanath Das¹, Tomáš Fürst¹, Soňa Gurská¹, Petr Džubák¹, Marián Hajdúch¹

¹Institute of Molecular and Translational Medicine, Palacky University in Olomouc

JoVE 55403

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Grant L. Lin¹, Michelle Monje²

¹Graduate Program in Neuroscience, Department of Neurology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, ²Departments of Neurology, Neurosurgery, Pathology and Pediatrics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine

JoVE 55360

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Jun Tang¹, Carlos Pérez-Medina^1,2, Yiming Zhao², Ahmad Sadique¹, Willem J. M. Mulder², Thomas Reiner¹

¹Department of Radiology, Memorial Sloan Kettering Cancer Center, ²Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai

JoVE 55271

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers

Richard Wang¹, Harris Wang¹, Zhixiang Wang¹

¹Department of Medical Genetics, Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta

JoVE 55027

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Lucas Tricoli¹, Deborah L. Berry², Chris Albanese¹

¹Department of Oncology, Lombardi Comprehensive Cancer Center, ²Department of Oncology, Georgetown University Medical Center

JoVE 55279

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Hiren J. Mehta¹, Michael A. Jantz¹

¹Division of Pulmonary/Critical care/Sleep Medicine, University of Florida College of Medicine

JoVE 54855

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Chenyu Zhang¹, Frank J. Lowery¹, Dihua Yu¹

¹Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center

JoVE 55085

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Irida Kastrati¹, Loruhama Delgado-Rivera², Gergana Georgieva³, Gregory R. J. Thatcher², Jonna Frasor¹

¹Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, ²Medicinal Chemistry and Pharmacognosy, College of Medicine, University of Illinois at Chicago, ³College of Pharmacy, University of Illinois at Chicago

JoVE 54798

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