JoVE Journal

Medicine

JoVE Medicine includes methods and experimental approaches for biomedical research and clinical medicine, including case studies, clinical procedures, surgeries, clinical trials, and animal models of disease.

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Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Maximilian Grab^1,2, Carina Hopfner³, Alena Gesenhues⁴, Fabian König^1,2, Nikolaus A. Haas³, Christian Hagl¹, Adrian Curta⁴, Nikolaus Thierfelder¹

¹Department of Cardiac Surgery, Ludwig Maximilian University Munich, ²Chair of Medical Materials and Implants, Technical University of Munich, ³Department Pediatric Cardiology and Pediatric Intensive Care, Ludwig Maximilian University Munich, ⁴Department of Radiology, Ludwig Maximilian University Munich

JoVE 62063

Methods Collection

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

Datta Singh Goolaub^1,2, Davide Marini^3,4, Mike Seed^4,5, Christopher K. Macgowan^1,2

¹Department of Medical Biophysics, University of Toronto, ²Division of Translational Medicine, The Hospital for Sick Children, ³Labatt Family Heart Centre, The Hospital for Sick Children, ⁴Department of Pediatrics, University of Toronto, ⁵Division of Pediatric Cardiology, The Hospital for Sick Children

JoVE 61953

Whole-Mount Immunofluorescence Staining, Confocal Imaging and 3D Reconstruction of the Sinoatrial and Atrioventricular Node in the Mouse

Ruibing Xia^1,2,3, Julia Vlcek^1,2, Julia Bauer^1,2,3, Stefan Kääb^1,3, Hellen Ishikawa-Ankerhold^1,2, Dominic Adam van den Heuvel^1,2, Christian Schulz^1,2,3, Steffen Massberg^1,2,3, Sebastian Clauss^1,2,3

¹University Hospital Munich, Department of Medicine I, Ludwig Maximilian University Munich, ²Walter Brendel Center of Experimental Medicine, Ludwig Maximilian University Munich, ³German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance

JoVE 62058

Methods Collection

Location, Dissection, and Analysis of the Murine Stellate Ganglion

Katharina Scherschel^1,2,3, Hanna Bräuninger^2,4, Klara Glufke², Christiane Jungen^2,4,5, Nikolaj Klöcker³, Christian Meyer^1,2,3

¹Division of Cardiology, EVK Düsseldorf, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, ²DZHK (German Centre for Cardiovascular Research), ³Institute of Neural and Sensory Physiology, Medical Faculty, Heinrich Heine University Düsseldorf, ⁴Clinic for Cardiology, University Heart & Vascular Centre, University Hospital Hamburg-Eppendorf, ⁵Department of Cardiology, Leiden University Medical Center

JoVE 62026

Methods Collection

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Arrigo Cattabriga*¹, Maria Adriana Cocozza*¹, Giulio Vara*¹, Francesca Coppola¹, Rita Golfieri¹

¹Department of Diagnostic and Specialty Medicine, Policlinico Sant'Orsola-Malpighi, University of Bologna

JoVE 61737

Obtaining Quality Extended Field-of-View Ultrasound Images of Skeletal Muscle to Measure Muscle Fascicle Length

Amy N. Adkins^1,4,5, Wendy M. Murray^1,2,3,4,5

¹Department of Biomedical Engineering, Northwestern University, ²Department of Physical Medicine & Rehabilitation, Northwestern University Feinberg School of Medicine, ³Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, ⁴Shirley Ryan AbilityLab, ⁵Edward Hines, Jr. VA Hospital

JoVE 61765

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Dolores T. Müller¹, Justus Toader¹, Benjamin Babic¹, Wolfgang Schröder¹, Jessica M. Leers¹, Christiane J. Bruns¹, Hans F. Fuchs¹

¹Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne

JoVE 61641

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells

Thais Bascuas^1,2, Martina Kropp^1,2, Nina Harmening^1,2, Mohammed Asrih¹, Zsuzsanna Izsvák³, Gabriele Thumann^1,2

¹Experimental Ophthalmology, University of Geneva, ²Department of Ophthalmology, University Hospitals of Geneva, ³Max Delbrück Center for Molecular Medicine

JoVE 61957

Methods Collection

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Christoph R. Behem¹, Till Friedheim¹, Sabine H. Wipper², Hans O. Pinnschmidt³, Michael F. Graessler¹, Catharina Gaeth⁴, Hannes Holthusen¹, Adina Rapp⁵, Timo Suntrop¹, Josephina Haunschild⁶, Christian D. Etz⁶, Constantin J. C. Trepte¹

¹Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, ²University Department for Vascular Surgery and Department of Operative Medicine, Medical University of Innsbruck, ³Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, ⁴Department of Vascular Medicine, University Heart and Vascular Center Hamburg (UHZ), ⁵Department of Cardiology, Rostock University Medical Center, ⁶University Department for Cardiac Surgery, Heart Center Leipzig

JoVE 62047

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti

Jeong-Eun Park*^1,2,3, Su Hoon Lee*^1,2, Dong Jun Park^1,2, Young Joon Seo^1,2, Sung Kyun Kim³

¹Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, ²Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, ³Department of Otorhinolaryngology Head and Neck Surgery, Hallym University College of Medicine

JoVE 61947

Avoiding Ischemia Reperfusion Injury in Liver Transplantation

Yixi Zhang*^1,2,3, Changjun Huang*^1,2,3, Weiqiang Ju*^1,2,3, Qiang Zhao^1,2,3, Maogen Chen^1,2,3, Linhe Wang^1,2,3, Dongping Wang^1,2,3, Linwei Wu^1,2,3, Zebin Zhu⁴, Shanzhou Huang⁵, Zhiheng Zhang^1,2,3, Caihui Zhu^1,2,3, Rongxing Xie^1,2,3, Yinghua Chen^1,2,3, Anbin Hu^1,2,3, Xiaofeng Zhu^1,2,3, Zhiyong Guo^1,2,3, Xiaoshun He^1,2,3

¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, ²Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, ³Guangdong Provincial International Cooperation Base of Science and Technology, ⁴Organ Transplant Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, ⁵Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences

JoVE 61485

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Elliott G. Richards*¹, Jenna M. Rehmer*², Melissa A. Mathes³, Emily L. Esakov¹, Chad Braley¹, Amy Joehlin-Price⁴, Andres Chiesa-Vottero⁴, Ofer Reizes^1,5

¹Cardiovascular and Metabolic Sciences, Lerner Research Institute; Women’s Health Institute, Cleveland Clinic, ²Women’s Health Institute, Cleveland Clinic, ³Department of Obstetrics and Gynecology, 983255 Nebraska Medical Center, University of Nebraska Medical Center, ⁴Anatomic Pathology, Cleveland Clinic, ⁵Gynecologic Oncology, Women’s Health Institute and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic

JoVE 61960

Assessing Whole-Body Lipid-Handling Capacity in Mice

Mingyang Huang¹, Noah Mathew¹, Yi Zhu¹

¹Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine

JoVE 61927

Methods Collection

Lymphatic and Blood Network Analysis During Obesity

Rafael S Czepielewski*¹, Alexandre Gallerand*^2,3, Jérôme Gilleron^2,4, Narges Khedher^2,3, Gwendalyn J. Randolph¹, Stoyan Ivanov^2,3

¹Department of Pathology and Immunology, Washington University School of Medicine, ²Université Côte d'Azur, ³Mediterranean Center of Molecular Medicine C3M, Team 13, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR1065, ⁴Mediterranean Center of Molecular Medicine C3M, Team 7, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR1065

JoVE 61814

Methods Collection

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Rodrigo Menezes Forti^1,2, Marilise Katsurayama^2,3, Lenise Valler^2,3, Andrés Quiroga^1,2, Luiz Simioni¹, Julien Menko⁴, Antonio L. E. Falcão³, Li Min Li^2,5, Rickson C. Mesquita^1,2

¹Institute of Physics, University of Campinas, ²Brazilian Institute of Neuroscience and Neurotechnology, ³Clinical Hospital, University of Campinas, ⁴Department of Emergency Medicine, Albert Einstein College of Medicine, ⁵School of Medical Sciences, University of Campinas

JoVE 61608

Methods Collection

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Anne Cornelissen*¹, Roberta Florescu*¹, Nicole Schaaps¹, Mamdouh Afify¹, Sakine Simsekyilmaz¹, Elisa Liehn*^1,2,3, Felix Vogt*¹

¹Division of Cardiology, Angiology, and Critical Care, University Hospital RWTH Aachen, ²Department for Operative Intensive Medicine, University Hospital RWTH Aachen, ³Institute for Pathology "Victor Babes"

JoVE 61442

Sleeve Gastrectomy in Mice using Surgical Clips

Jih-Hua Wei^1,2,3, Che-Hung Yeh⁴, Wei-Jei Lee⁵, Shing-Jong Lin^3,6,7,8,9, Po-Hsun Huang^3,6,7

¹Cardiovascular Division, Internal Medicine Department, Min-Sheng General Hospital, ²Department of Nutrition and Health Sciences, School of Healthcare Management, Kai-Nan University, ³Institute of Clinical Medicine, National Yang-Ming University, ⁴Food Science and Biotechnology, College of Biotechnology and Bioresources, University of Da-Yeh, ⁵Department of Surgery, Min-Sheng General Hospital, ⁶Department of Critical Care Medicine, Taipei Veterans General Hospital, ⁷Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, ⁸Division of Cardiology, Heart Center, Cheng-Hsin General Hospital, ⁹Taipei Medical University

JoVE 60719

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Deokho Lee*^1,2, Yukihiro Miwa*^1,2,3, Heonuk Jeong^1,2, Shin-ichi Ikeda^1,2, Yusaku Katada^1,2, Kazuo Tsubota^1,2,4, Toshihide Kurihara^1,2

¹Laboratory of Photobiology, Keio University School of Medicine, ²Department of Ophthalmology, Keio University School of Medicine, ³Animal eye care, Tokyo Animal Eye Clinic, ⁴Tsubota Laboratory, Inc.

JoVE 61865

Methods Collection

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Xu-Chun Chen*¹, Manmeet Sekhon*^1,2, Xue-Zhong Ma*¹, Justin Manuel¹, Sai Chung^1,2, Eddie He¹, Agata Bartczak¹, Sandra Fischer³, Cornelia Thoeni³, Graziano Oldani¹, Catia T. Perciani¹, Sonya MacParland^1,2,3, Ian McGilvray¹

¹Multi-Organ Transplant Program, University Health Network, ²Department of Immunology, University of Toronto, ³Department of Laboratory Medicine and Pathobiology, University of Toronto

JoVE 60628

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Bálint Károly Lakatos¹, Márton Tokodi¹, Erika Kispál¹, Béla Merkely¹, Attila Kovács¹

¹Semmelweis University Heart and Vascular Center

JoVE 61214

Methods Collection

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Guadalupe Estrada-Gutierrez¹, Eyerahi Bravo-Flores², Veronica Ortega-Castillo³, Veronica Flores-Rueda⁴, Ismael Mancilla-Herrera⁵, Salvador Espino Y Sosa⁶, Maribel Sánchez-Martínez², Otilia Perichart-Perera⁷, Mario Solis-Paredes⁸