JoVE Journal

Neuroscience

JoVE Neuroscience includes methods and techniques for studying the brain and nervous system; also featuring potential treatments for neurological conditions and diseases.

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Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Caitlin A. Murphy¹, Aeyal Raz^1,2, Sean M Grady¹, Matthew I Banks¹

¹Department of Anesthesiology, University of Wisconsin, ²Department of Anesthesiology, Rambam Health Care Campus, the Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology

JoVE 61333

Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound

Gerhard Leinenga¹, Liviu-Gabriel Bodea¹, Wee Kiat Koh¹, Rebecca M. Nisbet¹, Jürgen Götz¹

¹Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland

JoVE 61372

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Rianne Haumann*^1,2, Elvin ’t Hart*², Marc P. P. Derieppe², Helena C. Besse³, Gertjan J. L. Kaspers^1,2, Eelco Hoving², Dannis G. van Vuurden^1,2, Esther Hulleman^1,2, Mario Ries³

¹Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology, Cancer Center Amsterdam, ²Princess Máxima Center for Pediatric Oncology, ³Imaging Division, Utrecht University

JoVE 61269

Methods Collection

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Camilo A. Sanchez¹, Jackson Brougher², Kim C. Rahebi³, Catherine A. Thorn²

¹Department of Bioengineering, University of Texas at Dallas, ²School of Behavioral and Brain Sciences, University of Texas at Dallas, ³Texas Biomedical Device Center, University of Texas at Dallas

JoVE 61128

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Nicolás Stuardo^1,2, Guillermo Moya-Alvarado^1,3, Carolina Ramírez^1,3, Giampietro Schiavo⁴, Francisca C. Bronfman^1,3

¹Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, ²Department of Molecular and Cellular Biology, Faculty of Biological Sciences, Center for Aging and Regeneration (CARE UC), Pontificia Universidad Católica de Chile, ³Institute of Biomedical Sciences. Faculty of Medicine and Faculty of Life Sciences, Universidad Andrés Bello, ⁴Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and UK Dementia Research Institute at UCL, University College London Campus

JoVE 61262

Methods Collection

Pharmacological Validation of the Prepulse Inhibition of Startle Response in Larval Zebrafish using a Commercial Automated System and Software

Nancy Saana Banono^1,2, Camila V. Esguerra^1,2

¹Chemical Neuroscience Group, Centre for Molecular Medicine Norway (NCMM), Faculty of Medicine, University of Oslo, ²Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo

JoVE 61423

Minimizing Hypoxia in Hippocampal Slices from Adult and Aging Mice

Maja Djurisic¹

¹Department of Biology, Neurobiology, and Bio-X, Stanford University

JoVE 61377

Methods Collection

Measuring Statistical Learning Across Modalities and Domains in School-Aged Children Via an Online Platform and Neuroimaging Techniques

Julie M. Schneider¹, Anqi Hu¹, Jennifer Legault¹, Zhenghan Qi¹

¹Department of Linguistics and Cognitive Science, University of Delaware

JoVE 61474

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Bei Zhang¹, Binoy Joseph², Kathryn E. Saatman², Lei Chen²

¹College of Public Health, Shaanxi University of Chinese Medicine, ²Spinal Cord and Brain Injury Research Center, Department of Physiology, University of Kentucky

JoVE 61119

Methods Collection

Flow Cytometry Approach to Characterize Phagocytic Properties of Acutely-Isolated Adult Microglia and Brain Macrophages In Vitro

Supriya Ramesha¹, Sruti Rayaprolu¹, Srikant Rangaraju¹

¹Department of Neurology, Emory University

JoVE 61467

Methods Collection

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Isabel Mateos-White¹, Jaime Fabra-Beser¹, David de Agustín-Durán¹, Cristina Gil-Sanz¹

¹Estructura de Recerca Interdisciplinar en Biotecnología y Biomedicina (ERI BIOTECMED), Departamento de Biología Celular, Biología Funcional y Antropología Física, Universidad de Valencia

JoVE 61046

Methods Collection

A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model

Megan Rich¹, Quentin Whitsitt¹, Farah Lubin², Mark Bolding¹

¹Department of Radiology, University of Alabama at Birmingham, ²Department of Neurobiology, University of Alabama at Birmingham

JoVE 61113

Ex Vivo Myelination and Remyelination in Cerebellar Slice Cultures as a Quantitative Model for Developmental and Disease-Relevant Manipulations

Kimberle Shen¹, Tracy J. Yuen¹

¹Department of Neuroscience, Genentech Inc.

JoVE 61044

Methods Collection

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Pravin K. Wagley^1,2, John Williamson², Daria Skwarzynska³, Jaideep Kapur^2,4,5, Jennifer Burnsed^1,2

¹Department of Pediatrics, University of Virginia, ²Department of Neurology, University of Virginia, ³Neuroscience Graduate Program, University of Virginia, ⁴Brain Institute, University of Virginia, ⁵Department of Neuroscience, University of Virginia

JoVE 61346

Quantification of Macronutrients Intake in a Thermogenetic Neuronal Screen using Drosophila Larvae

Gonçalo M. Poças^1,2, Pedro M. Domingos*², Christen K. Mirth*¹

¹School of Biological Sciences, Monash University, ²Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA)

JoVE 61323

Culture of Neurospheres Derived from the Neurogenic Niches in Adult Prairie Voles

Daniela Ávila-González¹, Larry J. Young², Francisco Camacho¹, Raúl G. Paredes^1,3, Néstor F. Díaz⁴, Wendy Portillo¹

¹Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, ²Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, ³Escuela Nacional de Estudios Superiores Juriquilla, Universidad Nacional Autónoma de México, ⁴Departamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología

JoVE 61402

Methods Collection

Use of Real-Time Functional Magnetic Resonance Imaging-Based Neurofeedback to Downregulate Insular Cortex in Nicotine-Addicted Smokers

Mohit Rana^1,2, Sergio Ruiz^1,2, Andrea Sánchez Corzo^1,2, Axel Muehleck⁴, Sandra Eck⁴, César Salinas⁵, Francisco Zamorano^5,6, Claudio Silva⁵, Massimiliano Rea⁴, Anil Batra⁴, Niels Birbaumer^1,7,8, Ranganatha Sitaram^1,2,9