JoVE Journal

Neuroscience

JoVE Neuroscience includes methods and techniques for studying the brain and nervous system; also featuring potential treatments for neurological conditions and diseases.

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An Unbiased Approach of Sampling TEM Sections in Neuroscience

Stefan Wernitznig¹, Florian Reichmann², Mariella Sele¹, Christoph Birkl³, Johannes Haybäck^4,5, Florian Kleinegger⁴, Anna Birkl-Töglhofer⁴, Stefanie Krassnig⁴, Christina Wodlej⁴, Peter Holzer², Daniel Kummer¹, Elisabeth Bock¹, Gerd Leitinger¹

¹Department of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, ²Department of Pharmacology, Otto Loewi Research Center, Medical University of Graz, ³Division of General Neurology, Department of Neurology, Medical University of Graz, ⁴Institute of Pathology, Medical University of Graz, ⁵Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Anaelle da Costa*¹, Christophe Prehaud*¹, Florian Bakoa¹, Philippe Afonso², Pierre-Emmanuel Ceccaldi², Pierre Lafaye³, Monique Lafon¹

¹Institut Pasteur, CNRS UMR 3569, Unité de Neuroimmunologie Virale, ²Institut Pasteur, Unité d’Epidémiologie et de Pathophysiologie des Virus Oncogènes, Université Sorbonne Paris Cité/Paris Diderot, ³Institut Pasteur, PFIA, DTPS

Intracranial Pharmacotherapy and Pain Assays in Rodents

Erik Martinez¹, Haocheng Zhou¹, Jing Wang^1,2

¹Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, ²Department of Neuroscience and Physiology, New York University School of Medicine

Studying Brain Function in Children Using Magnetoencephalography

Hannah Rapaport^1,2, Robert A. Seymour^1,2,3, Paul F. Sowman^1,2, Nick Benikos^1,2, Elisabeth Stylianou^1,2, Blake W. Johnson^1,2, Stephen Crain^1,4, Wei He^1,2

¹ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, ²Department of Cognitive Science, Macquarie University, ³Aston Brain Centre, School of Life and Health Sciences, Aston University, ⁴Department of Linguistics, Macquarie University

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Uylissa A. Rodriguez^1,2, Yaping Zeng^1,2, Margaret A. Parsley^1,2, Bridget E. Hawkins^1,2, Donald S. Prough^1,2, Douglas S. DeWitt^1,2

¹Charles R. Allen Research Laboratories, Department of Anesthesiology, University of Texas Medical Branch, ²The Moody Project for Translational Traumatic Brain Injury Research, University of Texas Medical Branch

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Brandon Foreman¹, Daryn Cass², Jonathan Forbes², Laura B. Ngwenya^2,3

¹Department of Neurology and Rehabilitation Medicine, University of Cincinnati, ²Department of Neurosurgery, University of Cincinnati, ³Neurotrauma Center, University of Cincinnati Gardner Neuroscience Institute

Preparation of Rhythmically-active In Vitro Neonatal Rodent Brainstem-spinal Cord and Thin Slice

Samantha B. Palahnuk^1,2, Jonathan A. Abdala¹, Vadim V. Gospodarev³, Christopher G. Wilson¹

¹Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, ²Department of Biology, The College of New Jersey, ³Department of Neurosurgery, Loma Linda University

Dissection of Local Ca²⁺ Signals in Cultured Cells by Membrane-targeted Ca²⁺ Indicators

Hiroko Bannai^1,2, Matsumi Hirose², Fumihiro Niwa^2,3, Katsuhiko Mikoshiba²

¹Japan Science and Technology Agency, PRESTO, ²Laboratory for Developmental Neurobiology, RIKEN Center for Brain Science, ³École Normale Supèrieure, Institut de Biologie de l'ENS (IBENS), Institut national de la santè et de la recherche mèdicale (INSERM), Centre national de la recherche scientifique (CNRS), École Normale Supèrieure, PSL Research University

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Thomas A.W. Bolton^1,2, Delphine Jochaut³, Anne-Lise Giraud³, Dimitri Van De Ville^1,2

¹Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), ²Department of Radiology and Medical Informatics, University of Geneva, ³Department of Neuroscience, University of Geneva

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Melina Thetiot¹, Rémi Ronzano¹, Marie-Stéphane Aigrot¹, Catherine Lubetzki¹, Anne Desmazières¹

¹Sorbonne Université, Inserm, CNRS, Institut du Cerveau et de la Moelle épinière, ICM-GH Pitié-Salpétrière

Direct Injection of a Lentiviral Vector Highlights Multiple Motor Pathways in the Rat Spinal Cord

Kathleen M. Keefe¹, Ian P. Junker¹, Imran S. Sheikh¹, Thomas J. Campion¹, George M. Smith¹

¹Shriner's Pediatric Research Center, Temple University

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Nane Griem-Krey¹, Anders Bue Klein¹, Matthias Herth^1,2,3, Petrine Wellendorph¹

¹Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, ²Neurobiology Research Unit and CIMBI, Copenhagen University Hospital, ³Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Masaya Ikegawa*¹, Takashi Nirasawa*², Nobuto Kakuda¹, Tomohiro Miyasaka¹, Yuki Kuzuhara¹, Shigeo Murayama³, Yasuo Ihara⁴

¹Department of Life and Medical Systems, Doshisha University, ²Bruker Daltonics K.K., ³The Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, ⁴Graduate School of Brain Science, Doshisha University

Localization of the Locus Coeruleus in the Mouse Brain

Katharina Schmidt¹, Bilal Bari², Martina Ralle³, Clorissa Washington-Hughes¹, Abigael Muchenditsi¹, Evan Maxey⁴, Svetlana Lutsenko¹

¹Department of Physiology, Johns Hopkins University, School of Medicine, ²Department of Neuroscience, Johns Hopkins University, ³Department of Molecular and Medical Genetics, OHSU, ⁴X-ray science division, Advanced Photon Source, Argonne National Laboratory

Isolation of Primary Murine Skeletal Muscle Microvascular Endothelial Cells

Thomas Müntefering*¹, Alexander P.E. Michels*¹, Steffen Pfeuffer¹, Sven G. Meuth*¹, Tobias Ruck*¹

¹Institute for Translational Neurology and Neurology Clinic, University of Muenster

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

Skyler L. Jackman¹, Christopher H. Chen², Wade G. Regehr²

¹Vollum Institute, Oregon Health and Science University, ²Harvard Medical School

Long-term Sensory Conflict in Freely Behaving Mice

Filipa França de Barros^1,2, Julie Carcaud², Mathieu Beraneck^1,2

¹Integrative Neuroscience and Cognition Center, UMR8002, CNRS, ²Sorbonne Paris Cité, Université Paris Descartes

Bilateral Assessment of the Corticospinal Pathways of the Ankle Muscles Using Navigated Transcranial Magnetic Stimulation

Charalambos C. Charalambous^1,2, Jing Nong Liang^3,4, Steve A. Kautz^2,5, Mark S. George^5,6, Mark G. Bowden^2,5,7

¹Department of Neurology, New York University School of Medicine, ²Department of Health Sciences and Research, Medical University of South Carolina, ³Department of Physical Therapy, University of Nevada Las Vegas, ⁴Department of Health Professions, Medical University of South Carolina, ⁵Ralph H. Johnson VA Medical Center, ⁶Department of Psychiatry, Medical University of South Carolina, ⁷Division of Physical Therapy, Medical University of South Carolina

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice

Dongxiao Li*¹, Yundu Li*², Yunyun Tian¹, Zuoshang Xu³, Yansu Guo^1,4

¹Department of Neurology, Second Hospital of Hebei Medical University, ²No.2 Middle School of Shijiazhuang, ³Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, ⁴Key Laboratory of Hebei Neurology

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Ellen P. Hart¹, Ricardo Alvarez-Jimenez¹, Esther Davidse¹, Robert Jan Doll¹, Adam F. Cohen¹, Joop M.A. Van Gerven¹, Geert Jan Groeneveld¹

¹Centre for Human Drug Research (CHDR), Leiden

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Jordy Blanc¹, Hélène Roumes¹, Leslie Mazuel¹, Philippe Massot¹, Gérard Raffard¹, Marc Biran¹, Anne-Karine Bouzier-Sore¹

¹Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB), Unités Mixtes de Recherche (UMR) 5536, Centre National de la Recherche Scientifique (CNRS)/Université Bordeaux

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Ksenija Marinkovic^1,2, Lauren E. Beaton¹, Burke Q. Rosen^1,3, Joseph P. Happer⁴, Laura C. Wagner¹

¹Department of Psychology, San Diego State University, ²Department of Radiology, University of California San Diego, ³Department of Neurosciences, University of California San Diego, ⁴San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset

Misako Komatsu¹, Takaaki Kaneko^2,3, Hideyuki Okano^2,3, Noritaka Ichinohe^1,4

¹Laboratory for Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science, ²Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, ³Department of Physiology, Keio University School of Medicine, ⁴Department of Ultrastructural Research, National Center of Neurology and Psychiatry

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices

Fanny Etienne^1,2,3, Vincenzo Mastrolia^1,2,3, Luc Maroteaux^1,2,3, Jean-Antoine Girault^1,2,3, Nicolas Gervasi*^1,2,3, Anne Roumier*^1,2,3

¹Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-S 1270 Paris, France, ²Sorbonne Université, Paris, France, ³Institut du Fer à Moulin, Paris, France

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