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14-3-3 Proteins: A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are Phosphoserine and Phosphothreonine binding proteins involved in important cellular processes including Signal transduction; Cell cycle control; Apoptosis; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
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