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Acinar Cells: Cells lining the saclike dilatations known as acini of various glands or the lungs.

Lipid Digestion

JoVE 10832

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.

Lingual lipase is an enzyme secreted by the acinar cells of the sublingual gland that aids lipid digestion. Although found in saliva, it plays only a minimal role in breaking down lipids in the mouth. Interestingly, lingual lipase has a pH optimum of 3.5-6.0 and is not activated until chewed food enters the acidic environment of the stomach. Gastric lipase is an acidic lipase that is secreted by the gastric chief cells in the lining of the stomach. Lingual lipase and gastric lipase comprise the two acidic lipases found in the human digestive system. These lipases are active in the stomach but rapidly inactivated by bile acids in the duodenum. Together, gastric lipase and lingual lipase account for 10-30% of lipid hydrolysis that occurs in human adults, with gastric lipase contributing the most. Given the low concentrations of pancreatic lipase and bile salts in the neonatal phase, the acidic lipases are critical for lipid digestion and account for 50% of lipid hydrolysis in neonates. Bile contains bile salts, lecithin, and cholesterol-derived substances, so it acts as an emulsifier in the duodenum of the small i

 Core: Nutrition and Digestion

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

1Program in Developmental Biology, Baylor College of Medicine, 2Center for Cell and Gene Therapy, Texas Children's Hospital, and Houston Methodist Hospital, Baylor College of Medicine, 3Molecular and Cellular Biology Department, Baylor College of Medicine, 4Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, 5McNair Medical Institute, Baylor College of Medicine

JoVE 57599

 Developmental Biology

In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas

1Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, 2Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 3Division of Chemistry and Chemical Engineering, California Institute of Technology

JoVE 54016

 Developmental Biology

Imaging FITC-dextran as a Reporter for Regulated Exocytosis

1Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, 2Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, 3Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, 4Departments of Pathology and of Microbiology and Immunology and Sean N. Parker Center for Allergy and Asthma Research, School of Medicine, Stanford University

JoVE 57936

 Biology

Intravital Microscopy for Imaging Subcellular Structures in Live Mice Expressing Fluorescent Proteins

1Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch National Institute of Dental and Craniofacial Research, National Institutes of Health, 2Department of Biology, University of North Carolina at Chapel Hill, 3Department of Chemical & Biochemical Engineering and Department of Biomedical Engineering, Rutgers University

JoVE 50558

 Biology

Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Johns Hopkins University School of Medicine, 3Department of Dermatology, The Johns Hopkins University School of Medicine, 4Department of Surgery, Johns Hopkins University School of Medicine, 5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine, 6Yale Cancer Center, Yale School of Medicine, 7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine, 8Department of Pathology, The Johns Hopkins University School of Medicine

JoVE 4059

 Medicine
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