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Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by Angiotensin converting enzyme. The amino acid in position 5 varies in different species. To block Vasoconstriction and Hypertension effect of angiotensin Ii, patients are often treated with Ace inhibitors or with Angiotensin ii type 1 receptor blockers.

Intracellular Staining and Flow Cytometry to Identify Lymphocyte Subsets within Murine Aorta, Kidney and Lymph Nodes in a Model of Hypertension

1Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, 2Department of Molecular Physiology and Biophysics, Vanderbilt University, 3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University

JoVE 55266


 Immunology and Infection

Live Cell Imaging and 3D Analysis of Angiotensin Receptor Type 1a Trafficking in Transfected Human Embryonic Kidney Cells Using Confocal Microscopy

1Department of Biochemistry, Georgetown University Medical Center, 2Department of Medicine, Georgetown University Medical Center, 3Department of Physics, Georgetown University Medical Center, 4Department of Oncology, Georgetown University Medical Center

JoVE 55177


 Biology

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats

1Department of Physical Therapy, Marquette University, 2Medical College of Wisconsin, 3Department of Physiology, Medical College of Wisconsin, 4Graduate Programs of Nurse Anesthesia, Texas Wesleyan University, 5Office of Research, Medical College of Wisconsin

JoVE 56133


 Medicine

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

1Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), 2Institute of Sport Sciences, Faculty of Biology and Medicine, University of Lausanne, 3Neonatal Research Laboratory, Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital

Video Coming Soon

JoVE 58708


 JoVE In-Press

Estimation of Nephron Number in Whole Kidney Using the Acid Maceration Method

1Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, 2Department of Medicine, Division of Nephrology, Rush University Medical Center, 3Department of Medicine, Division of Nephrology, The University of Mississippi Medical Center, 4Department of Neurology, The University of Mississippi Medical Center

Video Coming Soon

JoVE 58599


 JoVE In-Press

Peptide and Protein Quantification Using Automated Immuno-MALDI (iMALDI)

1University of Victoria-Genome BC Proteomics Centre, 2Jewish General Hospital, McGill University, 3Dept of Biochemistry and Microbiology, University of Victoria, 4Proteomics Centre, Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, 5Gerald Bronfman Department of Oncology, Jewish General Hospital

JoVE 55933


 Chemistry

Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion

1Department of Medical Physiology, Hamamatsu University School of Medicine, 2Division of Vascular Surgery, Second Department of Surgery, Hamamatsu University School of Medicine, 3Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, 4Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine

JoVE 55763


 Medicine

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

1Department of Dietetics and Nutrition, University of Arkansas for Medical Sciences, 2Department of Nutrition, Food and Exercise Sciences, Florida State University, 3Center for Advancing Exercise and Nutrition Research on Aging (CAENRA), Florida State University

JoVE 55605


 Chemistry

Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice

1Department of Environmental Medicine, New York University School of Medicine, Tuxedo, 2Division of Allergy, Pulmonary, & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, 3Division of Pulmonary Medicine, New York University School of Medicine

JoVE 50023


 Immunology and Infection

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

1Cardiovascular and Aging Research, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg, 2Kidney Control of Homeostasis, Swiss National Centre of Competence in Research, 3System Physiology, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg

JoVE 53718


 Biology

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

1Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University, 2Department of Vascular Surgery, University of Tokyo, 3Department of Vascular Surgery, VA Connecticut Healthcare Systems, 4Department of Vascular Surgery, International University of Health and Welfare Mita Hospital

JoVE 53905


 Medicine

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 2Department of Medicine, Vanderbilt University Medical Center, 3Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 4Cardiovascular Institute, Maine Medical Center

JoVE 54005


 Biology

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency

1Transplant and Stem Cell Immunobiology Lab, University Heart Center Hamburg, 2Department of Surgery, Transplant and Stem Cell Immunobiology Lab, University of California San Francisco (UCSF), 3Cardiovascular Research Center (CVRC) and DZHK German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, 4Cardiovascular Surgery, University Heart Center Hamburg

JoVE 54839


 Medicine

Near-infrared Fluorescence Imaging of Abdominal Aortic Aneurysms

JoVE 10394

Source: Arvin H. Soepriatna1, Kelsey A. Bullens2, and Craig J. Goergen1

1 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana

2 Department of Biochemistry, Purdue University, West Lafayette, Indiana Near-infrared fluorescence (NIRF) imaging is an exciting optical technique that utilizes fluorescent probes to visualize complex biomolecular assemblies in tissues. NIRF imaging has many advantages over conventional imaging methods for noninvasive imaging of diseases. Unlike single photon emission computed tomography (SPECT) and positron emission tomography (PET), NIRF imaging is rapid, high-throughput, and does not involve ionizing radiation. Furthermore, recent developments in engineering target-specific and activatable fluorescent probes provide NIRF with high specificity and sensitivity, making it an attractive modality in studying cancer and cardiovascular disease. The presented procedure is designed to demonstrate the principles behind NIRF imaging and how to conduct in vivo and ex vivo experiments in small animals to study a variety of diseases. The specific example shown here employs an activatab


 Biomedical Engineering

Quantitative Strain Mapping of an Abdominal Aortic Aneurysm

JoVE 10480

Authors: Hannah L. Cebull1, Arvin H. Soepriatna1, John J. Boyle2 and Craig J. Goergen1 1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 2Mechanical Engineering & Materials Science, Washington University in St. Louis, St Louis, Missouri

The mechanical behavior of soft tissues, such as blood vessels, skin, tendons, and other organs, are strongly influenced by their composition of elastin and collagen, which provide elasticity and strength. The fiber orientation of these proteins depends on the type of soft tissue and can range from a single preferred direction to intricate meshed networks, which can become altered in diseased tissue. Therefore, soft tissues often behave anisotropically on the cellular and organ level, creating a need for three-dimensional characterization. Developing a method for reliably estimating strain fields within complex biological tissues or structures is important to mechanically characterize and understande disease. Strain represents how soft tissue relatively deforms over time, and it can be described mathematically through various estimations. Acquiring image data over time allows deformation and strain to be estimated. However, all medica


 Biomedical Engineering

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

1Département de sciences cliniques, CHUV, Université de Montréal, St-Hyacinthe, QC, 2Département d'obstetriques et de gynécologie, CHU Ste-Justine Research Centre, Université de Montréal, 3Département de neurosciences, CHU Ste-Justine Centre de recherche, Université de Montréal, 4Centre de recherche en reproduction animale (CRRA), Université de Montréal, St-Hyacinthe, QC

JoVE 52581


 Developmental Biology

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