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Bundle of His: Small band of specialized Cardiac muscle fibers that originates in the Atrioventricular node and extends into the membranous part of the interventricular septum. The bundle of His, consisting of the left and the right bundle branches, conducts the electrical impulses to the Heart ventricles in generation of Myocardial contraction.

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

1Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 2Department of Echocardiography, Shanghai Institute of Medical imaging, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 3Department of Cardiac surgery, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University

JoVE 56439

 Biology

The Cardiac Cycle

JoVE 10887

The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).

Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the ventricles before they contract. The electrical impulses are then conducted by the bundle of His and propagated to the left and right bundle branches. The signal is then conducted by Purkinje fibers in the ventricular walls, inducing ventricular contraction and pumping blood out of the heart. During diastole (relaxation), the heart fills with blood, and the cycle is repeated.

 Core: Circulatory and Pulmonary Systems
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