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Caspase 2: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with Card signaling adaptor proteins. Caspase 2 plays a role in Apoptosis by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its Messenger rna.

Genome-Wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

1Children's Hospital of Eastern Ontario (CHEO) Research Institute, 2Department of Biology, Microbiology and Immunology, University of Ottawa, 3Department of Pediatrics, University of Ottawa, 4Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary

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JoVE 56913


 JoVE In-Press

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