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Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.

An Introduction to Drosophila melanogaster

JoVE 5082

Drosophila melanogaster, also known as the fruit fly, is a powerful model organism widely used in biological research that has made significant contributions to the greater scientific community over the last century. First, this video introduces the fruit fly as an organism, including its physical characteristics, life cycle, environment, and diet. Next, the reasons why fruit flies…

 Biology I

Drosophila melanogaster Embryo and Larva Harvesting and Preparation

JoVE 5094

Drosophila melanogaster embryos and larvae are easy to manipulate and develop rapidly by mechanisms that are analogous to other organisms, including mammals. For these reasons, many researchers utilize fly embryos and larvae to answer questions in diverse fields ranging from behavioral to developmental biology. Prior to experimentation, however, the embryos and larvae must first be…

 Biology I

Animal Behavior- Concept

JoVE 10582

Drosophila as a Model Organism

The common fruit fly, Drosophila melanogaster, is a widely used model organism in biology, though it may be more commonly recognized as a fruit-loving pest. There are multiple reasons that make D. melanogaster an excellent experimental organism: their roughly two-week generation time allows studying multiple generations, they are…

 Lab Bio

Drosophila Development and Reproduction

JoVE 5093

One of the many reasons that make Drosophila an extremely valuable organism is that the molecular, cellular, and genetic foundations of development are highly conserved between flies and higher eukaryotes such as humans. Drosophila progress through several developmental stages in a process known as the life cycle and each stage provides a unique platform for developmental…

 Biology I

Drosophila Maintenance

JoVE 5084

Drosophila melanogaster, commonly known as fruit flies, are a frequently used model organism for life science research. Although starting a collection of these critters may seem as easy as leaving a banana on your kitchen counter for too long, a productive fly colony in the lab requires careful husbandry and maintenance.


This video demonstrates the necessary steps for…

 Biology I

Drosophila Larval IHC

JoVE 5106

Immunohistochemistry (IHC) is a technique used to visualize the presence and location of proteins within tissues. Drosophila larvae are particularly amenable to IHC because of the ease with which they can be processed for staining. Additionally, the larvae are transparent, meaning that some tissues can be visualized without the need for dissection.


In IHC, proteins are…

 Biology I

Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster

1The Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, 2CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 3CAS Key Laboratory of Infection and Immunity (CASKLII), Institute of Biophysics, Chinese Academy of Sciences, 4Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

JoVE 58845

 Immunology and Infection

Animal Behavior - Student Protocol

JoVE 10583

Making Choice Chambers
Before beginning the experiments, use one of the Sharpies from the lab table to trace a line around the circumference of the bottom of both bottles. One line should be 1 cm from the base of the bottle and the other should be 1.5 cm from the base of the bottle.
Use a razor blade to make a small cut in each bottle at the mark. …

 Lab Bio

Animal Behavior - Prep Student

JoVE 10630

D. Melanogaster Care
Obtain the Drosophila melanogaster specimens at least two weeks before the experiment to allow the specimens to acclimate to the lab room conditions. NOTE: 25 Drosophila adults produce about 50 new adults in two weeks. Each colony-housing container should consist of a clean vial, 1.5 – 3 cm of…

 Lab Bio

Genetics of Organisms - Prep Student

JoVE 10619

REF and WEF Fly Genetics
To prepare for the experiment, be sure to obtain cultures of Drosophila melanogaster at least two weeks ahead of the planned experiment day. NOTE: Because adult females store sperm after mating, you will need this time to generate virgin females by breeding the flies.
You should get two stock cultures: wildtype,…

 Lab Bio

Genetics of Organisms- Concept

JoVE 10557

Mendelian Genetics

Evolution is caused by changes in the genetic composition of populations. In the field of population genetics, scientists model this process as changes in the frequency of alleles at individual genetic loci. This simple representation of how evolution occurs dates to Gregor Mendel’s analysis of trait inheritance patterns in pea plants, first presented in 1865.…

 Lab Bio

Evolutionary Relationships- Concept

JoVE 10561

Humans have been attempting to properly classify living things since Aristotle made the first attempt during the 4th century BC. Aristotle’s system was improved upon during the Renaissance and then, subsequently, by Carolus Linnaeus in the mid 1700’s. These more formal classification and organization systems grouped species by their physical similarity to one another. For example,…

 Lab Bio

Invertebrate Lifespan Quantification

JoVE 5338

Many animals naturally stop growing upon reaching adulthood, after which they undergo aging or "senescence" until dying. The amount of time between an organism\'s birth and death is called its lifespan, which can be influenced by various biological and environmental factors. By exposing organisms to different growth conditions, scientists can better understand the factors affecting lifespan.…

 Developmental Biology

High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay

1Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 2Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 3Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center

JoVE 55892

 Neuroscience

Two Algorithms for High-throughput and Multi-parametric Quantification of Drosophila Neuromuscular Junction Morphology

1Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 2Microscopical Imaging Centre (MIC), Radboud University Medical Center, 3Department of Biology, Universidad Autónoma de Madrid, 4Department of Clinical and Experimental Medicine, Linköping University, 5Department of Pathology, Radboud University Medical Center

JoVE 55395

 Neuroscience

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

1Department of Molecular and Human Genetics, Baylor College of Medicine, 2Program in Developmental Biology, Baylor College of Medicine, 3Department of Pediatrics, Section of Neurology and Developmental Neuroscience, Baylor College of Medicine, 4Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, 5Department of Neuroscience, Baylor College of Medicine

JoVE 59658

 Genetics

Drosophila Courtship Conditioning As a Measure of Learning and Memory

1Department of Human Genetics, Radboud University Medical Center, 2Radboud Institute of Molecular Life Sciences, Radboud University, 3Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Radboud University, 4Research Institute of Molecular Pathology, Vienna, Austria, 5Department for Health Evidence, Radboud University Medical Center, 6Janelia Research Campus, Howard Hughes Medical Institute, 7Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, 8Department of Biology, Faculty of Science, Western University

JoVE 55808

 Neuroscience
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