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A reduction in brain oxygen supply due to Anoxemia (a reduced amount of oxygen being carried in the blood by Hemoglobin), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to Brain death or a Persistent vegetative state. Histologically, this condition is characterized by neuronal loss which is most prominent in the Hippocampus; Globus pallidus; Cerebellum; and inferior olives.
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