Islets of Langerhans:
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the
Pancreas among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete
Insulin. Alpha cells (5-20%) secrete
Glucagon.
Pp cells (10-35%) secrete
Pancreatic polypeptide. Delta cells (~5%) secrete
Somatostatin.
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JoVE Biology
Joshua C. Neuman1, Nathan A. Truchan2, Jamie W. Joseph3, Michelle E. Kimple2
1Department of Nutrional Sciences, University of Wisconsin-Madison, 2Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, 3School of Pharmacy, University of Waterloo
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Erik J. Zmuda1, Catherine A. Powell1,2, Tsonwin Hai1,2,3
1Molecular and Cellular Biochemistry, Center for Molecular Neurobiology, The Ohio State University, 2Integrated Biomedical Science Graduate Program, The Ohio State University, 3Comprehensive Cancer Center, The Ohio State University
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JoVE Medicine
Anna U. Eriksson*1, Christoffer Svensson*1, Andreas Hörnblad1, Abbas Cheddad1, Elena Kostromina1, Maria Eriksson1, Nils Norlin1, Antonello Pileggi2, James Sharpe3, Fredrik Georgsson4, Tomas Alanentalo1, Ulf Ahlgren1
1Umeå Centre for Molecular Medicine, Umeå University, 2Cell Transplant Center, Diabetes Research Institute, University of Miami,, 3EMBL-CRG Systems Biology Program, Centre for Genomic Regulation, Catalan Institute of Research and Advanced Studies, 4Dept. of Computing Science, Umeå University
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Chen Huang1, Guoqiang Gu1
1Department of Cell and Development Biology, Vanderbilt University Medical School
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Raymond C. Pasek1, Taylor E. Kavanaugh2, Craig L. Duvall2, Maureen A. Gannon1,3
1Department of Medicine, Vanderbilt University Medical Center, 2School of Engineering, Vanderbilt University, 3Department of Veterans Affairs, Tennessee Valley Health Authority
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Madina Makhmutova1, Tao Liang2, Herbert Gaisano2, Alejandro Caicedo1, Joana Almaça1
1Department of Medicine, University of Miami, 2Department of Medicine, University of Toronto
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JoVE Medicine
Zhengshan Zhao1, Yassan Abdolazimi1, Neali A. Armstrong1, Justin P. Annes1
1Department of Medicine, Division of Endocrinology, Stanford University School of Medicine
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JoVE Medicine
Patrick T. Fueger1,2, Angelina M. Hernandez2, Yi-Chun Chen2, E. Scott Colvin1,2
1Department of Pediatrics, Indiana University School of Medicine, 2Department of Cellular & Integrative Physiology, Indiana University School of Medicine
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Natalie D. Stull1, Andrew Breite2, Robert McCarthy2, Sarah A. Tersey1, Raghavendra G. Mirmira1,3,4
1Department of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 2VITACYTE, LLC, 3Department of Medicine, Indiana University School of Medicine, 4Department of Cellular and Integrative Physiology, Indiana University School of Medicine
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Gregor Bötticher1, Dorothèe Sturm1, Florian Ehehalt1, Klaus P. Knoch2, Stephan Kersting1, Robert Grützmann1, Gustavo B. Baretton3, Michele Solimena2, Hans D. Saeger1
1Department of GI-, Thorax- and Vascular Surgery, University Hospital Carl Gustav Carus, University of Technology Dresden, 2Molecular Diabetology, Paul Langerhans Institute Dresden, 3Department of Pathology, University Hospital Carl Gustav Carus, University of Technology Dresden
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Oanh H. Do1, Jiun T. Low1, Peter Thorn1
1School of Biomedical Sciences, The University of Queensland
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Joe Fu-Jiou Lo1, Yong Wang2,3, Zidong Li1, Zhengtuo Zhao1, Di Hu1, David T. Eddington3, Jose Oberholzer2,3
1Department of Mechanical Engineering, University of Michigan-Dearborn, 2Department of Surgery/Transplant, University of Illinois at Chicago, 3Department of Bioengineering, University of Illinois at Chicago
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JoVE Medicine
Charles Zhang1, Arthur T. Suckow2, Steven D. Chessler1,3
1Pediatric Diabetes Research Center, University of California, San Diego, 2Janssen Research & Development, 3Department of Medicine, University of California, San Diego
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JoVE Medicine
Dorothée Sturm1,2, Lorella Marselli3, Florian Ehehalt1,2, Daniela Richter1, Marius Distler2, Stephan Kersting1,2, Robert Grützmann2, Krister Bokvist4, Philippe Froguel5, Robin Liechti6, Anne Jörns7, Paolo Meda8, Gustavo Bruno Baretton9, Hans-Detlev Saeger2, Anke M. Schulte10, Piero Marchetti3, Michele Solimena1
1Molecular Diabetology, Paul Langerhans Institute Dresden, 2Department of GI-, Thoracic- and Vascular Surgery, University Hospital Carl Gustav Carus, University of Technology Dresden, 3Department of Endocrinology and Metabolism, Metabolic Unit University of Pisa, 4Labs DC0522, Lilly Corporate Center, 5Genomics, Faculty of Medicine Imperial College London, 6Vital-IT, SIB Swiss Institute of Bioinformatics, 7Clinical Biochemistry, Hannover Medical School, 8Cell Physiology and Metabolism, Medical School, University of Geneva, 9Department of Pathology, University Hospital Carl Gustav Carus, University of Technology Dresden, 10R&D DIAB Division / Translational Medicine, Sanofi-Aventis
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Midhat H. Abdulreda1,2, Alejandro Caicedo1,3,4, Per-Olof Berggren1,5
1Diabetes Research Institute, University of Miami Miller School of Medicine, 2Department of Surgery, University of Miami Miller School of Medicine, 3Department of Medicine, University of Miami Miller School of Medicine, 4Department of Physiology & Biophysics, University of Miami Miller School of Medicine, 5The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet
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JoVE Medicine
Martha L. Campbell-Thompson1, Tiffany Heiple1, Emily Montgomery1, Li Zhang1, Lynda Schneider1
1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida
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Corinne A. Hoesli1, Roger L. J. Kiang2, Kamini Raghuram2, René G. Pedroza3, Karen E. Markwick1, Antonio M. R. Colantuoni1, James M. Piret2
1Department of Chemical Engineering, McGill University, 2Michael Smith Laboratories & Department of Chemical and Biological Engineering, University of British Columbia, 3Michael Smith Laboratories & Department of Pharmaceutical Sciences, University of British Columbia
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JoVE Immunology and Infection
Wen Jing Sim1, Frano Malinarich1, Anna-Marie Fairhurst2, John Edward Connolly1,3
1Translational Immunology, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 2Singapore Immunology Network, 3Institute of Biomedical Studies, Baylor University
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JoVE Genetics
Volodymyr Petrenko*1, Camille Saini*2, Laurent Perrin*1, Charna Dibner1
1Department of Medical Specialties, Division of Endocrinology, Diabetes, Hypertension and Nutrition, Diabetes Center, University of Geneva Medical School, Institute of Genetics and Genomics in Geneva (iGE3), 2Population Epidemiology Unit (UEP), Community Medicine, Geneva University Hospital
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JoVE Biology
Abraham Kim1, German Kilimnik1, Charles Guo1, Joshua Sung1, Junghyo Jo2, Vipul Periwal2, Piotr Witkowski3, Philip Dilorio4, Manami Hara1
1Department of Medicine, University of Chicago, 2Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 3Department of Surgery, University of Chicago, 4Diabetes Division, University of Massachusetts
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Meirigeng Qi1, Barbara Barbaro1, Shusen Wang1, Yong Wang1, Mike Hansen1, Jose Oberholzer1
1Department of Surgery, University of Illinois, Chicago
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JoVE Medicine
Ana D. Lopez1, Ayse G. Kayali1, Alberto Hayek1, Charles C. King1
1Pediatric Diabetes Research Center, Department of Pediatrics, University of California, San Diego
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JoVE Biology
Chiara Greggio*1, Filippo De Franceschi*1, Manuel Figueiredo-Larsen*2, Anne Grapin-Botton1,2
1Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, 2DanStem, University of Copenhagen
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JoVE Biology
Michael Winkler1, Nancy Trieu2, Tao Feng2, Liang Jin2, Stephanie Walker2, Lipi Singh2, Hsun Teresa Ku2,3
1Department of Biotechnology & Bioinformatics, California State University Channel Islands, 2Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of City of Hope, 3The Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope
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Mingming Liu1, Xiaoyan Zhang1, Bingwei Li1, Bing Wand1, Qingbin Wu1, Fei Shang1, Ailing Li1, Hongwei Li1, Ruijuan Xiu1
1Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College
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Gregory L. Szot1, Pavel Koudria1, Jeffrey A. Bluestone1
1Diabetes Center, University of California, San Francisco - UCSF
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Tiziana A.L. Brevini1, Georgia Pennarossa1, Sara Maffei1, Alessandro Zenobi1, Fulvio Gandolfi1
1Laboratory of Biomedical Embryology, Unistem, Centre for Stem Cell Research, Università degli Studi di Milano
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JoVE Biology
Alex H. Tuttle*1, Matthew M. Rankin*1, Monica Teta1, Daniel J. Sartori1, Geneva M. Stein1, Gina J. Kim1, Cristina Virgilio1, Anne Granger1, Di Zhou1, Simon H. Long1, Alisa B. Schiffman1, Jake A. Kushner1
1Division of Endocrinology and Diabetes, Children’s Hospital of Philadelphia, Institute of Diabetes Obesity and Metabolism, Institute for Regenerative Medicine, Department of Pediatrics, University of Pennsylvania-School of Medicine
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JoVE Medicine
Martha L. Campbell-Thompson1, Emily L. Montgomery1, Robin M. Foss1, Kerwin M. Kolheffer1, Gerald Phipps1, Lynda Schneider1, Mark A. Atkinson1
1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida
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Sofie De Groef1, Gunter Leuckx1, Naomi Van Gassen1, Willem Staels1, Ying Cai1, Yixing Yuchi1, Violette Coppens1, Nico De Leu1, Yves Heremans1, Luc Baeyens1, Mark Van de Casteele1, Harry Heimberg1
1Diabetes Research Center, Vrije Universiteit Brussel
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Abraham Kim1, German Kilimnik1, Manami Hara1
1Department of Medicine, University of Chicago
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Alona Epshtein1, Lina Sakhneny1, Limor Landsman1
1Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University
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JoVE Medicine
Omaditya Khanna1, Jeffery C. Larson2, Monica L. Moya3, Emmanuel C. Opara4, Eric M. Brey2,5
1Department of Chemical and Biological Engineering, Illinois Institute of Technology, 2Department of Biomedical Engineering, Illinois Institute of Technology, 3Department of Biomedical Engineering, University of California at Irvine, 4Wake Forest Institute for Regenerative Medicine and Department of Biomedical Engineering, Wake Forest University Health Sciences, 5Research Service, Hines Veterans Administration Hospital
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JoVE Immunology and Infection
Achille Broggi1,2, Clara Cigni1, Ivan Zanoni1,2,3, Francesca Granucci1,3
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, 2Boston Children's Hospital, Division of Gastroenterology, Harvard Medical School, 3Humanitas Clinical and Research Center
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JoVE Developmental Biology
Emily C. McGaugh1,2,3, M. Cristina Nostro1,2,3
1Toronto General Research Institute, University Health Network, 2McEwen Centre for Regenerative Medicine, University Health Network, 3Department of Physiology, University of Toronto
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JoVE Medicine
Grace Fergusson1, Mélanie Ethier1, Bader Zarrouki1,2, Ghislaine Fontés1, Vincent Poitout1,2
1Montreal Diabetes Research Center, CRCHUM, 2Department of Medicine, University of Montreal
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Meirigeng Qi1, Barbara Barbaro1, Shusen Wang1, Yong Wang1, Mike Hansen1, Jose Oberholzer1
1Department of Surgery, University of Illinois, Chicago
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JoVE Bioengineering
Bradley P. Weegman1, Ahmad Essawy2, Peter Nash2, Alexandra L. Carlson2, Kristin J. Voltzke3, Zhaohui Geng2, Marjan Jahani2, Benjamin B. Becker2, Klearchos K. Papas4, Meri T. Firpo2
1Radiology, University of Minnesota, 2Medicine, University of Minnesota, 3School of Public Health, University of Minnesota, 4Surgery, University of Arizona
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JoVE Medicine
Rongying Li1,2, Kazuhiro Oka1,2,3, Vijay Yechoor1,2,3
1Department of Medicine, Baylor College of Medicine, 2Division of Diabetes, Endocrinology & Metabolism, Diabetes & Endocrinology Research Center, Baylor College of Medicine, 3Department of Molecular & Cellular Biology, Baylor College of Medicine
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JoVE Biology
Maria Jaramillo1, Ipsita Banerjee1,2
1Department of Bioengineering, University of Pittsburgh, 2Department of Chemical Engineering, University of Pittsburgh
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JoVE Bioengineering
Matthew L. Skiles1, Suchit Sahai1, James O. Blanchette2
1Biomedical Engineering Program, University of South Carolina, 2Chemical Engineering Department, University of South Carolina
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JoVE Bioengineering
Michael P. Storm1, Ian Sorrell2, Rebecca Shipley3, Sophie Regan2, Kim A. Luetchford1, Jean Sathish2, Steven Webb4, Marianne J. Ellis1
1Department of Chemical Engineering and Centre for Regenerative Medicine, University of Bath, 2MRC Centre for Drug Safety Science and Institute of Translational Medicine, University of Liverpool, 3Mechanical Engineering, University College London, 4Department of Applied Mathematics, Liverpool John Moores University
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JoVE In-Press
Elisa Peranzoni*1, Houcine Bougherara*1, Sarah Barrin1, Audrey Mansuet-Lupo2,3, Marco Alifano4, Diane Damotte2,3, Emmanuel Donnadieu1
1Institut Cochin, Inserm U1016-CNRS UMR8104, Université Paris Descartes, 2Department of Pathology, Paris Centre University Hospitals, Université Paris Descartes, 3INSERM U1138, Cancer and Immune Escape, Cordeliers Research Center, University Pierre and Marie Curie, 4Department of Thoracic Surgery, Paris Centre University Hospitals, University Paris Descartes
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JoVE Immunology and Infection
Vishnu Priya Bollampalli1, Susanne Nylén1, Antonio Gigliotti Rothfuchs1
1Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet
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Gabriel Mizraji*1,2, Hadas Segev*1, Asaf Wilensky*2, Avi-Hai Hovav*1
1Institute of Dental Sciences, Hebrew University - Hadassah Medical Center, 2Department of Periodontology, Hebrew University - Hadassah Medical Center
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George Zhang1, Yudan Chi1, Yi-Chieh Nancy Du1
1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
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JoVE In-Press
Reni Ajpy1,2, Szu-Yi Chou1,2,3
1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University
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Adeola F. Adewola1, Yong Wang1, Tricia Harvat1, David T. Eddington2, Dongyoung Lee1, Jose Oberholzer1,2
1Department of Surgery, University of Illinois, Chicago, 2Department of Bioengineering, University of Illinois, Chicago
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Peter Westenskow1,2, Zack Sedillo1,2, Ashley Barnett2, Martin Friedlander1,2
1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Lowy Medical Research Institute
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Sudhanshu Bhushan1, Ferial Aslani1, Zhengguo Zhang1, Tim Sebastian1, Hans-Peter Elsässer2, Jörg Klug1
1Institut für Anatomie und Zellbiologie, Justus-Liebig-Universität Gießen, 2Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg
