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Myocardial Infarction: Necrosis of the Myocardium caused by an obstruction of the blood supply to the heart (Coronary circulation).

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

1Department of Surgery, The Ohio State University, 2Heart and Lung Research Institute, The Ohio State University, 3Department of Cardiovascular Medicine, The Ohio State University

JoVE 1781

 Medicine

Pericardiocentesis

JoVE 10236

Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA


The heart lies within the pericardium, a relatively inelastic fibrous sac. The pericardium has some compliance to stretch when fluid is slowly introduced into the pericardial space. However, rapid accumulation overwhelms pericardial…

 Emergency Medicine and Critical Care

Physiology of the Circulatory System- Concept

JoVE 10625

Homeostasis

Conditions in the external environment of an organism can change rapidly and drastically. To survive, organisms must maintain a fairly constant internal environment, which involves continuous regulation of temperature, pH, and other factors. This balanced state is known as homeostasis, which describes the processes by which organisms maintain their optimal internal…

 Lab Bio

Cardiac Exam I: Inspection and Palpation

JoVE 10071

Source: Suneel Dhand, MD, Attending Physician, Internal Medicine, Beth Israel Deaconess Medical Center


The cardiac assessment is one of the core examinations performed by almost every physician whenever encountering a patient. Disorders of the cardiac system are among the most common reasons for hospital admission, with conditions ranging…

 Physical Examinations I

Combined SPECT and CT Imaging to Visualize Cardiac Functionality

JoVE 10396

Source: Alycia G. Berman, James A. Schaber, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana


Here we will demonstrate the fundamentals of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging using mice. The technique involves injecting a…

 Biomedical Engineering

Photoacoustic Tomography to Image Blood and Lipids in the Infrarenal Aorta

JoVE 10395

Source: Gurneet S. Sangha and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana


Photoacoustic tomography (PAT) is an emerging biomedical imaging modality that utilizes light generated acoustic waves to obtain compositional information from tissue. PAT can be used to image …

 Biomedical Engineering

Near-infrared Fluorescence Imaging of Abdominal Aortic Aneurysms

JoVE 10394

Source: Arvin H. Soepriatna1, Kelsey A. Bullens2, and Craig J. Goergen1


1 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana


2 Department of Biochemistry, Purdue University, West Lafayette, Indiana


Near-infrared fluorescence (NIRF) imaging…

 Biomedical Engineering

Compound Administration IV

JoVE 10214

Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN


There are many commonly used routes for compound administration in laboratory mice and rats. Protocols may, however, require the use of the less commonly used routes: intracardiac, footpad, and retro-orbital injections. Specialized…

 Lab Animal Research

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

1Department of Neurological Surgery, Ohio State University, 2Department of Surgery, Ohio State University, 3Department of Surgery, Duke University, 4Department of Internal Medicine, Ohio State University

JoVE 57981

 Medicine

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 3Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong

JoVE 53447

 Bioengineering

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

1Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, 2Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad de Murcia, 3Institute of Virology and Immunology (IVI), 4Departamento de Anatomía y Anatomía Comparada, Facultad de Veterinaria, Universidad de Murcia, 5Unidad de Trasplante Hematopoyético y Terapia Celular, Departamento de Hematología, Hospital Universitario Virgen de la Arrixaca, IMIB, Universidad de Murcia

JoVE 56699

 Medicine

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

1Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, University of Rostock, 2Physikalisch-Technische Bundesanstalt, 3Department of Radiology and Neuroradiology, Ernst-Moritz-Arndt-University Greifswald, 4Electron Microscopy Center, University of Rostock

JoVE 55567

 Medicine

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell (MSC) Spheroids Primed in 3-D Cultures Under Xeno-free Conditions

1Department of Biology, University of Mary Hardin-Baylor, 2Department of Pediatrics, University of Texas Medical Branch, 3Multi-Organ Support Technology Task Area, U.S. Army Institute of Surgical Research, 4Internal Medicine, Texas A&M University Health Science Center

JoVE 55126

 Developmental Biology

The Aortic Ring Co-culture Assay: A Convenient Tool to Assess the Angiogenic Potential of Mesenchymal Stromal Cells In Vitro

1Create Fertility Centre, 2Department of Physiology, University of Toronto, 3Department of Obstetrics and Gynecology, University of Toronto, 4Department of Medical Sciences, University of Toronto, 5Department of Obstetrics and Gynecology, Women's College Hospital

JoVE 56083

 Developmental Biology

High-Throughput Analysis of Optical Mapping Data Using ElectroMap

1Institute of Cardiovascular Sciences, University of Birmingham, 2EPSRC Centre for Doctoral Training in Physical Sciences for Health, School of Chemistry, University of Birmingham, 3School of Computer Science, University of Birmingham, 4Institute of Clinical Sciences, University of Birmingham, 5Institute of Microbiology and Infection, School of Biosciences, University of Birmingham

JoVE 59663

 Medicine

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 2Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 3Mellen Center for Treatment and Research in Multiple Sclerosis, Neurological Institute, Cleveland Clinic

JoVE 59511

 Neuroscience

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

1Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), 2Institute of Sport Sciences, Faculty of Biology and Medicine, University of Lausanne, 3Neonatal Research Laboratory, Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital

JoVE 58708

 Behavior

Retrospective MicroRNA Sequencing: Complementary DNA Library Preparation Protocol Using Formalin-fixed Paraffin-embedded RNA Specimens

1Department of Research, Hackensack University Medical Center, 2Department of Medical Sciences, Seton Hall University, 3Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 4Department of Nephrology and Hypertension, Hadassah - Hebrew University Medical Center

JoVE 57471

 Genetics

Human Pluripotent Stem Cell Culture on Polyvinyl Alcohol-Co-Itaconic Acid Hydrogels with Varying Stiffness Under Xeno-Free Conditions

1Department of Chemical and Materials Engineering, National Central University, 2Department of Botany and Microbiology, King Saud University, 3Cathay Medical Research Institute, Cathay General Hospital, 4Graduate Institute of Systems Biology and Bioinformatics, National Central University, 5Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, 6Department of Internal Medicine, Taiwan Landseed Hospital, 7Department of Zoology, Bharathiar University, 8Thiruvalluvar University

JoVE 57314

 Bioengineering

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis After Coronary Angioplasty

1Experimental Metabolism and Clinical Research Laboratory & Regenerative Medicine and Tissue Engineering Laboratory, 2Hemodynamics Unit, Cardiology Department, Centro Médico Nacional "20 de Noviembre" ISSSTE, 3Laboratorio de Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez

Video Coming Soon

JoVE 60504

 JoVE In-Press
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