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An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

1Africa Centre for Health and Population Studies, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa, 2Unit D11, Jembi Health Systems, 3Academic Medical Center, Department of Global Health, Amsterdam Institute for Global Health and Development (AIGHD), University of Amsterdam, 4Division of Infectious Diseases and Geographic Medicine, Centre for AIDS Research, Stanford Medical School

JoVE 51242


 Medicine

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats

1Department of Physical Therapy, Marquette University, 2Medical College of Wisconsin, 3Department of Physiology, Medical College of Wisconsin, 4Graduate Programs of Nurse Anesthesia, Texas Wesleyan University, 5Office of Research, MCW, Medical College of Wisconsin

Video Coming Soon

JoVE 56133


 JoVE In-Press

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

1Motion Analysis Laboratory, Kennedy Krieger Institute, 2Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, 3Johns Hopkins University School of Medicine, 4Department of Neurology, Johns Hopkins University School of Medicine

JoVE 53449


 Medicine

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

1Department of Pediatric Oncology/Hematology, VU University Medical Center, 2Department of Hematology, VU University Medical Center, 3Department of Medical Oncology, VU University Medical Center, 4Department of Clinical Genetics, VU University Medical Center, 5Division of General and Transplant Surgery, Azienda Ospedaliera Universitaria Pisana, Universita’ di Pisa, 6Amsterdam Immunology and Rheumatology Center, VU University Medical Center, 7Princess Máxima Center for Pediatric Oncology, 8Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, 9Institute of Nanoscience and Nanotechnology, CNR-Nano

JoVE 54714


 Cancer Research

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

1BIOS Lab on a Chip group, MIRA Institute for Biomedical Technology and Technical Medicine, MESA+ Institute for Nanotechnology and Max Planck Center for Complex Fluid Dynamics, University of Twente, 2Microsystems, Eindhoven University of Technology, 3Applied Stem Cell Technologies, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente

Video Coming Soon

JoVE 56334


 JoVE In-Press

Experimental Multiscale Methodology for Predicting Material Fouling Resistance

1Department of Mechanical Engineering, Massachusetts Institute of Technology, 2Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 3Department of Mechanical Engineering, University of Arkansas, 4Department of Materials Science and Engineering, Massachusetts Institute of Technology

Video Coming Soon

JoVE 52952


 JoVE In-Press

Series and Parallel Resistors

JoVE 10289

Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN

This experiment demonstrates how current is distributed in resistors connected in series or parallel, and thus describes how to calculate the total "effective" resistance. Using Ohm's law, it possible to convert between the voltage and current through a resistance, if the resistance is known. For two resistors connected in series, (meaning that they are wired one after the other), the same current will flow through them. The voltages will add up to a "total voltage", and thus, the total "effective resistance" is the sum of the two resistances. This is sometimes called a "voltage divider" because the total voltage is divided between the two resistors in proportion to their individual resistances. For two resistors connected in parallel, (meaning that they are both wired between two shared terminals), the current is split between the two while they share the same voltage. In this case, the reciprocal of the total effective resistance will equal the sum of the reciprocals of the two resistances. Series and parallel resistors are a key component to most circuits and influence how electricity


 Physics II

Ohm's Law

JoVE 10116

Source: Andrew Duffy, PhD, Department of Physics, Boston University, Boston, MA

This experiment investigates Ohm's law, which relates current, voltage, and resistance.

One goal of the experiment is to become familiar with circuit diagrams and the terminology involved in basic circuits, such as resistor, resistance, current, voltage, and power supply. By the end of the experiment, familiarity is gained with how to wire up a circuit and how to measure both the current passing through a circuit component and the potential difference, or voltage, across it. In a circuit, a battery or power supply provides a voltage measured in volts (V) that makes the charge flow. Other elements in the circuit, such as light bulbs or resistors (which are often just long narrow wires wound into coils) limit the rate at which the charge flows. The rate of flow of the charge is known as current measured in amperes (A), or amps for short, and the degree to which resistors and light bulb filaments limit the flow is known as their resistance measured in ohms (Ω). This experiment involves an exploration of Ohm's law, which relates voltage, current, and resistance. This experiment also explores the difference between a basic circuit component called a resistor, a


 Physics II

Whole-cell Patch-clamp Recordings of Isolated Primary Epithelial Cells from the Epididymis

1School of Life Science and Technology, ShanghaiTech University, 2Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 3University of Chinese Academy of Sciences, 4Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University

JoVE 55700


 Developmental Biology

RC/RL/LC Circuits

JoVE 10318

Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN

Capacitors (C), inductors (L), and resistors (R) are each an important circuit element with distinct behaviors. A resistor dissipates energy and obeys Ohm's law, with its voltage proportional to its current. A capacitor stores electrical energy, with its current proportional to the rate of change of its voltage, while an inductor stores magnetic energy, with its voltage proportional to the rate of change of its current. When these circuit elements are combined, they can cause the current or voltage to vary with time in various, interesting ways. Such combinations are commonly used to process time- or frequency-dependent electrical signals, such as in alternating current (AC) circuits, radios, and electrical filters. This experiment will demonstrate the time-dependent behaviors of the resistor-capacitor (RC), resistor-inductor (RL), and inductor-capacitor (LC) circuits. The experiment will demonstrate the transient behaviors of RC and RL circuits using a light bulb (resistor) connected in series to a capacitor or inductor, upon connecting to (and switching on) a power supply. The experiment will also demonstrate the oscillatory behavior of an LC circuit.


 Physics II

Elbow Exam

JoVE 10207

Source: Robert E. Sallis, MD. Kaiser Permanente, Fontana, California, USA

The elbow is a hinged joint that involves the articulation of 3 bones: the humerus, radius, and ulna. It is a much more stable joint than the shoulder, and because of that, the elbow has less range of motion. The elbow and its structures are prone to significant injuries, particularly with repetitive motion. Lateral and medial epicondylitis (also called tennis elbow and golfer's elbow) are two common diagnoses and often occur as a result of occupational activities. When examining the elbow, it is important to remove enough clothing so that the entire shoulder and elbow can be inspected. It is important to compare the injured elbow to the uninvolved side. A systematic evaluation of the elbow includes inspection, palpation, range of motion (ROM) testing, and special tests, including maneuvers to evaluate ligamentous stability and stretch tests to accentuate pain caused by epicondylitis.


 Physical Examinations III

Genetic Manipulation of the Plant Pathogen Ustilago maydis to Study Fungal Biology and Plant Microbe Interactions

1Institute for Microbiology, Heinrich-Heine University Düsseldorf, 2Bioeconomy Science Center (BioSC), 3Department of Genetics, Institute of Applied Biosciences, Karlsruhe Institute of Technology, 4Cluster of Excellence in Plant Sciences (CEPLAS), Heinrich-Heine University Düsseldorf

JoVE 54522


 Genetics

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

1Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 2Department of Basic Biomedical Science, Universidad Europea de Madrid, 3Human Biology Program, School of Integrative and Global Majors, University of Tsukuba, 4Laboratory of Nosocomial Infections, Department of Bacteriology, Centro Nacional de MicrobiologÍa, Instituto de Salud Carlos III, 5Division of Microbiology, Department of Medicine, School of Medicine, Universidad Complutense, 6Biology of Gram-Positive Pathogens, Department of Microbiology, Institut Pasteur, Paris, France, 7ERL3526, CNRS, Paris, France

JoVE 55087


 Immunology and Infection

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