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RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in Gene silencing functions, especially Rna interference (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, Double-stranded) by the same ribonuclease, Dicer, that generates miRNAs (Micrornas). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
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