Show Advanced Search


Containing Text
- - -
Filter by author or institution
Filter by publication date
October, 2006
Filter by journal section

Filter by science education

Self Administration: Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.

Assessment of Ultrasonic Vocalizations During Drug Self-administration in Rats

1College of Pharmacy, Division of Pharmacology and Toxicology, University of Texas at Austin, 2The Waggoner Center of Addiction and Alcohol Research, University of Texas at Austin, 3Department of Psychology, University of Michigan, 4Institute for Neuroscience, University of Texas at Austin, 5Department of Psychology, University of Texas at Austin

JoVE 2041


Self-administration Studies

JoVE 5427

Behavioral reinforcement induced by the rewarding feelings following substance use sometimes leads to addiction, which is demonstrated by increased self-administration. Drug self-administration studies in rodents model human behavior during drug abuse. These models are useful in understanding the neurobiological behavior of addiction in order to help scientists discover new treatments for drug dependence. This video reviews the concepts underlying self-administration studies. A general protocol of self-administration is discussed, which includes description of necessary equipment and different routes of administration commonly employed. Some modified protocols used to model more complex aspects of addiction, such as progressive ratio schedule and extinction, are also explained. Finally, experiments conducted in current addiction research labs will be examined.

 Behavioral Science

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Addiction

1Center for Addiction Research, University of Texas Medical Branch, 2Department of Neurology, University of Texas Medical Branch, 3Department of Pathology, University of Texas Medical Branch, 4Department of Pharmacology and Toxicology, University of Texas Medical Branch, 5Institute for Translational Sciences, University of Texas Medical Branch, 6Mitchell Center for Neurodegenerative Disease, University of Texas Medical Branch

Video Coming Soon

JoVE 55864

 JoVE In-Press

Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats

1Interdepartmental Neuroscience Program, Yale University, 2Department of Biotechnical and Clinical Laboratory Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, 3Department of Psychiatry, Yale School of Medicine, 4Department of Cellular and Molecular Physiology, Yale School of Medicine

JoVE 52468


Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

1Diagnostic Radiology, Yale University, 2Psychiatry, Yale University, 3Yale PET Center, Yale University, 4Biomedical Engineering, Yale University, 5Nuclear Medicine, Massachusetts General Hospital, 6Radiological Sciences, University of California, Irvine

JoVE 50358


An Introduction to Reward and Addiction

JoVE 5425

Consequences play a major role in controlling our behavior. If the consequence is a reward, then it encourages the associated behavior. Rewards can come in many forms such as a pleasant feeling, money, or food. However, sometimes an individual engages in compulsive behavior despite of negative consequences, and this state is known as addiction. Administration of addictive substances is neurochemically rewarding, which ultimately causes a loss of control in limiting the intake. Scientists aim to better understand the mechanisms behind these concepts and subsequently develop new therapies for treating substance abuse disorders. JoVE's introduction to reward and addiction explains the neuroanatomical components of the reward pathway. This is followed by some of the important questions asked by behavioral researchers such as how does our brain chemistry change in response to drug use. Prominent methods section reviews some of the tools being employed in the field, like self-administration protocols. Finally, the video discusses example experiments conducted in labs interested in investigating reward and addiction.

 Behavioral Science

Tickling, a Technique for Inducing Positive Affect When Handling Rats

1Center for the Study of Animal Well-being, Department of Integrative Physiology and Neuroscience, Washington State University, 2Canadian Council on Animal Care, 3Department of Animal Sciences, Center for Animal Welfare Science, College of Agriculture, Purdue University, 4Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences

Video Coming Soon

JoVE 57190

 JoVE In-Press

An Introduction to Behavioral Neuroscience

JoVE 5210

Behavioral neuroscience is the study of how the nervous system guides behavior, and how the various functional areas and networks within the brain correlate to specific behaviors and disease states. Researchers in this field utilize a wide variety of experimental methods ranging from complex animal training techniques to sophisticated imaging experiments in human subjects. This video first offers a historical overview of some of the major milestones that lead to our current understanding of the brain’s control over behavior. Then, some of the fundamental questions asked by behavioral neuroscientists are presented, which all involve the study of neural correlates, or specific brain regions whose activation is responsible for a given function. Next, prominent methods used to answer those questions are reviewed for both human and animal subjects, such as operant conditioning and functional neuroimaging. Finally, experimental applications of these techniques are presented, including animal training using a Skinner box, and the use of electroencephalography to investigate human neurological disease.


More Results...