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Systemic Inflammatory Response Syndrome: A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or Hypothermia <36 degrees C; (2) Tachycardia >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) Leukocytosis >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, Sirs can also be associated with noninfectious insults such as Trauma; Burns; or Pancreatitis. If infection is involved, a patient with Sirs is said to have Sepsis.
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