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Vascular Endothelial Growth Factor Receptor-1: A 180-kDa Vegf receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for Vegf receptor binding and signal transduction.
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