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Wnt Signaling Pathway: A complex signaling pathway whose name is derived from the Drosophila Wg gene, which when mutated results in the wingless phenotype, and the vertebrate Int gene, which is located near integration sites of Mouse mammary tumor virus. The signaling pathway is initiated by the binding of Wnt proteins to cells surface Wnt receptors which interact with the Axin signaling complex and an array of second messengers that influence the actions of Beta catenin.

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

1Department of Biomedical Science, The Bateson Centre, University of Sheffield, 2Institute of Genetic Medicine, Newcastle University, 3Department of Cardiovascular Science, The Bateson Centre, University of Sheffield, 4School of Biochemistry, University of Bristol, 5Biology Department, University of York

JoVE 53162


 Developmental Biology

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

1Department of Surgery and Translational Medicine (DCMT), University of Florence, 2Neurofarba Department, University of Florence, 3Department of Traumatology and General Orthopedics, Azienda Ospedaliera Universitaria Careggi

JoVE 53884


 Cancer Research

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