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Bioengineering

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JoVE Journal Bioengineering
Modellering äggstockscancer flercelliga Sfäroid Beteende i en dynamisk 3D Peritoneal mikroanordning
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Modellering äggstockscancer flercelliga Sfäroid Beteende i en dynamisk 3D Peritoneal mikroanordning

Article DOI: 10.3791/55337-v • 11:34 min • February 18th, 2017
February 18th, 2017 •
*1, *1, *2, 2, 3, 3, 4, 2, 1
1School of Biological Sciences, University of Hong Kong, 2Department of Mechanical Engineering, University of Hong Kong, 3Department of Medicine, University of Hong Kong, 4Department of Biomedical Sciences, Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institutes of City University of Hong Kong
* These authors contributed equally

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För att studera äggstockstumörprogression i en fysiologiskt relevant modell, flercelliga spheroids odlades i en mikroanordning under simulerad vätskeflöde. Denna dynamiska 3D-modell emulerar intraperitoneal miljö med de cellulära och mekaniska komponenter där äggstockscancer metastas inträffar.

Tags

Bioteknik äggstockscancer mikrofluidik skjuvspänning peritoneala mesotelceller flercelliga sfäroider 3D kultur co-kultur
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