Metabolism-directed cellular ethology: novel technical approaches
University of Alberta in Edmonton
David Vergote is an Associate Lecturer in the Faculté Saint-Jean of the University of Alberta in Edmonton, Canada...
Energy management is a factor that plays a decisive role in most cellular behavior in response to stress. Should the cell engage in cell division? Should it expand and grow? Will it survive? Will it die? If so, which mechanism will be the most appropriate? Under biotic or abiotic stress conditions, the amount of energy available will serve as a guide to how the cell ends up behaving. A better understanding of how cells acquire, store and use their energy has important implications in the unraveling of mechanisms underlying neurodegenerative disorders, cancer, infectious diseases, among other physiological and pathological conditions. This collection aims at bringingtogether a wide range of technical advances developed to measure how cells gather energy and how the amount of available energy guides the cellular response to stress. Approaches to be included in this collection may include enzymatic in vitro assays, microscopy-based techniques, mitochondria-dependent or –independent cellular assays as well as ways to measure metabolic rate in vivo in well-established models. However, we also welcome submissions adapting established techniques to novel model organisms. We hope this collection will be a useful catalog for any researchers (either early in their career or more established) interested in metabolism-directed cellular behavior and will lead to fruitful collaborations.