Emerging approaches to elucidate neuro-immune interactions.
JoVE will publish text articles after the peer review, which on average takes two months after the manuscript submission. We will film and add corresponding videos to our website when laboratories and facilities in affected areas reopen.
University of California
Dr. Lillian Cruz-Orengo laboratory focuses on neuroimmune interactions at the blood-brain barrier (BBB), with the...
The last two decades have witnessed major paradigm shifts in our understanding of the functional communication between the immune and nervous systems. The scientific community has rejected the notion that the central nervous system is an absolute immune-privileged site(as defined 70 years ago), and thus many new and exciting frontiers in neuro-immune interactions need to be addressed. Similarly, there is compelling evidence for neuro-immune interactions in the peripheral nervous system. Some of the neurological disorders associated (either directly or indirectly) with a perturbed neuroimmune communication include: (1) autism spectrum disorder, (2) Alzheimer’s disease, (3) amyotrophic lateral sclerosis, (4) chronic inflammatory demyelinating polyneuropathy, (5) diabetic peripheral neuropathy, (6) encephalitis, (7) Guillan-Barre syndrome, (8) multiple sclerosis, (9) myasthenia gravis, (10) neuritis, (11) neuropsychiatric lupus, (12) primary brain tumors, (13) stroke, and (14) trauma. Thus, it is imperative to gain a better understanding of the immunobiology of the nervous system, the neurobiology of the immune system, and the physiology of the neuroimmune interactions in health and disease. We are in dire need of innovative technologies and methodologies to better study this system. This method collection will compile novel approaches that are used to understand the bilateral communication, interaction and synergy between these two systems. Due to the fact that complex techniques rely heavily on the skills and competence of the user, we consider JoVE to be an excellent mechanism to publish these methods in an instructive and collaborative way, facilitating the training of current and future researchers in the field.