Kidney disease models
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Division of Nephrology
Yoshiyuki Morishita, MD., PhD., is a professor of the Division of Nephrology, Department of Integrated Medicine, Saitama...
Kidney disease (such as chronic kidney disease (CKD) and acute kidney injury (AKI)) is a worldwide public health problem. Kidney diseases involve many types of cells, including mesangial cells, endothelial cells, epithelial cells (podocyte) and tubular cells. Additionally, there are many types of kidney disease rodent models, such as: (1) CKD (diabetic kidney disease, chronic glomerular disease, renal sclerosis, renal fibrosis and renal involvement of collagen diseases) and (2) AKI (Ischemia-reperfusion, sepsis induced and drug/toxin induced). This methods collection details how to purify, culture and analyze various renal cells, as well as how to induce and analyze kidney disease rodent models. These models are interesting and helpful for researchers engaged in the study of the physiology and pathology of kidney diseases.
1Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, 2Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University