In vitro modeling systems of respiratory illnesses and diseases
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University of Girona
Dr. Tura-Ceide is a researcher Miguel Servet type with a consolidated research experience for over 15 years in the field...
Charité – Universitätsmedizin Berlin
Dr. Robert Szulcek is Professor of Physiology in the department of Physiology at the Charitè -...
The lung is the primary organ, in humans and many animals, that guarantees efficient gas exchange with the ambient air. To perform its highly specialized function, the lung features a specific cellular and structural build-up, possesses special biomechanical and biophysical properties, and is highly vascularized. When lung function is compromised, the consequences can be fatal.
The diversity and often multifactorial nature of lung diseases, the frequently unspecific symptoms, and limitations to medical imaging present current research with many challenges. A major part of our knowledge has been derived from animal models. However, significant differences exist in lung development and physiology between different species. In consequence, results are difficult to translate to patients. Thus, there is an unmet need for in vitro human lung models.
With this methods collection, we aim to minimize the translational gap between animals and humans by facilitating the use of in vitro pulmonary disease models by a wide audience. We are seeking tools and techniques that enable the development and testing of new strategies for diagnosis; to explore pathological mechanisms; to test drugs, treatments, and guide therapy. We accept manuscripts from a variety of fields and topics that include, but are not limited to, protocols for lung-on-a-chip systems; tissue engineering and tissue printing; primary human cell isolations; human pluripotent stem cell derived lung tissue generation; culture and co-culture models; and methods that allow exploration of lung structure and composition, such as decellularization and imaging protocols.
1Department of Pulmonary Diseases, Amsterdam UMC, VU University Medical Center, Amsterdam Cardiovascular Sciences (ACS), 2BIOS Lab-on-a-Chip group, University of Twente, 3Applied Stem Cell Technologies Group, University of Twente, 4Department of Cardio-thoracic Surgery, Amsterdam UMC, VU University Medical Center, 5Institute of Physiology, Charité-Universitätsmedizin, 6German Heart Center