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Methods Collections

Zebrafish models of central nervous system disorders

Collection Overview

Neurological disorders have a high global prevalence. However, the molecular mechanisms mediating these disorders remain poorly understood. Animal models play a significant role in better understanding the pathophysiology of a variety of diseases afflicting humans and also help in the identification of potential therapeutic targets. Zebrafish (Danio rerio) has recently emerged as a powerful preclinical model for a wide range of brain disorders. Zebrafish based behavioral models have been successfully employed to better understand the neural and molecular aspects of a spectrum of CNS conditions i.e., epilepsy, schizophrenia, anxiety, Alzheimer’s disease, Parkinson’s disease, and substance abuse-related disorders. Both larval and adult zebrafish has proven to be valuable for translational neuropharmacology and drug discovery research. The zebrafish genome has orthologues corresponding to an extensive number of disease-related genes in humans. Zebrafish models are particularly useful for studying genotype-phenotype and genotype-drug-phenotype relationships. The high sensitivity of zebrafish to known antipsychotic and other CNS agents provides researchers with an ideal model organism capable of identifying molecular targets for therapy and empirical testing of their hypotheses. This collection aims to bring together the experimental protocols and approaches that have been developed using zebrafish to model a variety of neurological, neuropsychiatric and neurodegenerative conditions. Such models would provide important insights as to how zebrafish models have improved CNS disease modeling and the discovery of novel drug targets and candidates. The collection would serve as a valuable resource for researchers who aim to utilize such models in their laboratories to improve understanding of complex brain disorders.


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