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Biomedical photoacoustic imaging: From benchtop to bedside

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Methods Collections
Biomedical photoacoustic imaging: From benchtop to bedside

Guest Editors
Srivalleesha Mallidi

Tufts University

Dr. Srivalleesha Mallidi received her Masters and PhD Degree in Biomedical Engineering from the University of Texas at…

Mithun Kuniyil Ajith Singh


Dr. Mithun Kuniyil Ajith Singh is an engineering scientist with extensive experience in preclinical and clinical…

Collection Overview

Medical imaging offers crucial structural, functional, and molecular insights on various pathologies and therefore can aid in precise surgical procedures or customizable therapeutic courses. Deep-tissue high-resolution images with excellent contrast is of paramount interest for the diagnosis and therapeutic monitoring of ailments. Photoacoustic (PA) imaging, a modality based on optical absorption properties of the tissue, can provide information at scalable ultrasonic resolution and deeper penetration depth. This technique allows for unprecedented preclinical and clinical opportunities in obtaining functional and molecular insights on malignancies and overcomes the diffusion limit, a barrier that hinders the deep-tissue imaging capabilities of any high-resolution optical imaging modality. PA imaging can also seamlessly be integrated with the ubiquitous ultrasound imaging and can enable dual-mode imaging in one point-of-care platform due to the shared acoustic detection. Several PA imaging systems (microscopy, tomography) have been developed over the past two decades and this promising technique is currently undergoing an exciting transition with a focus on standardization, portability, low-cost and real-time acquisition speed.  Several efforts are also ongoing in developing  exogenous PA contrast agents to obtain molecular information of malignancies. Given the excitement around this rapidly growing field, the time is ripe to gather a visual methodological record of various PA imaging based methodologies. This Methods Collection on PA imaging will bring together topics of interest including, but not limited to, phantom development, procedure standardization, technology development, and multiple preclinical and clinical applications.

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