Alternative rodent models of brain injury and post-injury assessment
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Ben-Gurion University of the Negev (BGU)
Academic position: Senior lecturer.
Education: Ph.D. degree and post-doctorate studies...
Animal models are an important tool to evaluate the pathophysiology of cerebral injury and to advance the development of novel treatment options for improving neurological outcomes. Appropriate animal models are valued for their reproducibility and standardization, and their ability to provide direct access to brain tissue. Historically, the two most common techniques for studying neurological damage have been focal insult through intramural middle cerebral artery occlusion and inducing traumatic brain injury by external force using a weight drop. Following cerebral insult, measured outcomes in determining the extent of neurological injury often include a behavioral neurological severity score or histologic examination of cerebral edema, infarct zone, and/or blood-brain barrier permeability. Over the last decade, however, a variety of innovative methods have been developed. The objective of this collection is to present new, state-of-the-art techniques available to induce cerebral insult and to investigate subsequent neurological damage. We believe these novel approaches provide more practical, accurate, cost-efficient, and ethically-favorable options to measure neurological injury, and may promote future studies to better understand and treat its associated consequences.
1Division of Anesthesia and Critical Care, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 2Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 3Department of Anesthesiology, Yale University School of Medicine, 4Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, 5Department of microbiology and immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev