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Methods Collections > Zebrafish models for exploring early stages of neurological diseases 

Chris Shaw

Affiliation: University of British Columbia

I am a full professor (since 2003) in the Faculty of Medicine at the University of British Columbia with appointments to several departments: Ophthalmology and Visual Sciences (primary appointment) and Pathology. I am also a member of two graduate programs: Experimental Medicine and Neuroscience. My primary research interests include the Guamanian neurological disease ALS-parkinsonism dementia complex (ALS-PDC), zebrafish and other in vivo models of ALS, the role of aluminum in neurological diseases across the life span, and the role of signaling errors in neural development. Recently my laboratory has begun to look in more detail at gene-toxin interactions and synergies in disease onset and this avenue has been greatly facilitated by our continuing use of zebrafish. Many of these subjects have formed the basis for a book I wrote for Wiley and Sons in 2017, Neural Dynamics of Neurological Disease. We have also begun studies in mice to try to evaluate the ability of the copper homeostasis regulating compound CuATSM as a future therapeutic to prevent motor neuron loss in ALS. While preliminary, the data so far suggest a strong protective effect of CuATSM.

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