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Methods Collections > Assessment of lesion-specific transcriptional and epigenetic alterations in breast cancer

Haider Hassan

Affiliation: Western University

Dr. Haider M. Hassan is a specialist in the field of epigenetics and bioinformatics. He completed his Ph.D. training at Western University in 2018 and is currently studying epigenetic dysregulation in liver cancer as a Post-Doctoral Associate. This work involves a conditional knockout mouse model of Thymine DNA Glycosylase (TDG), which plays an important role in active DNA methylation. Specifically, livers of pre-tumor and tumor samples are isolated and sequenced at the transcriptomic and epigenetic level to delineate tumor suppressive pathways that are TDG dependent in vivo. Dr. Haider Hassan hopes to uncover novel epigenetic biomarkers of liver cancer to aid early detection of liver malignancies. His work also holds the potential to provide new treatments of liver cancer, which is often diagnosed at later stages and is associated with high mortality in patients. 

 

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