Dr. James N. Sleigh completed his Medical Research Council (MRC)-funded DPhil at the University of Oxford (2009-2012) working on the neuromuscular diseases spinal muscular atrophy (SMA) and Charcot-Marie-Tooth disease (CMT). During a four-year Sir Henry Wellcome Postdoctoral Fellowship (2014-2018) from the Wellcome Trust, Dr. Sleigh continued his research on the mechanisms underlying the 2D subtype of CMT (CMT2D) at the Queen Square Institute of Neurology, University College London (UCL). Now funded by a MRC Career Development Award (2019-2024), Dr. Sleigh is a Senior Research Fellow in the Department of Neuromuscular Diseases at UCL, running his own small research group.
Using CMT2D as a paradigm, Dr. Sleigh is studying the causes of selective motor and sensory nerve degeneration and the mechanisms underpinning the dynamic process of axonal transport. By improving understanding of neuropathic pathways and associated pathologies, his principal aim is to generate effective, pre-clinical gene therapies for genetic peripheral nerve diseases.