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Prolonged lifespan and delayed childbearing have prompted the research of reliable methods to preserve fertility for later in life. Such interventions that heavily rely o…
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Cardiovascular diseases remain a major health and economic burden worldwide. This is a consequence to the poor regenerative ability of the adult mammalian heart to repair…
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In addition to establishing the functional advances in the potential of stem cell secretome, recent years have drawn significant attention to the use of adipose-derived s…
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In addition to establishing the functional advances in the potential of stem cell secretome, recent years have drawn significant attention to the use of adipose-derived s…
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Medical-engineering cooperation plays an important role in the development of orthopedic surgery. In recent years, due to the combination of medical discovery and enginee…
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Genome editing technology facilitates our understanding of genes which are responsible for disease onset and progression. In this collection, we try to summarize state-of…
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Skeletal disorders are a prominent category of clinical conditions. These include common diseases such as osteoporosis and subsequent fractures which affect ~ 20 million …
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This collection will provide a series of methodologies to study epigenetic mechanisms mediating skeletal muscle differentiation and regeneration using a mouse, human samp…
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Cancer stem cells (CSCs) are a subpopulation of cancer cells that are considered to be responsible for tumor initiation, metastasis, and drug resistance. CSCs have self-r…
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The five pairs of murine mammary glands are ectoderm-derived appendages that are formed in the embryo from embryonic day 10.5. The study of the murine mammary glands has …
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Human pluripotent stem cells, including embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) are invaluable tools to study human diseases in vitro. Th…
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During embryonic development, hematopoietic cells originate from a series of hematopoietic waves that occur at different time points and produce cells with specific chara…
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Primary cells are the most accurate representation of the tissue of origin. They are removed straight from the tissue and treated to put them in the best culture conditio…
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The striated (cardiac and skeletal) muscles of vertebrates are specialized organs critical for their locomotion and survival. Both types of muscles experience marked func…
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Aberrant implantation is one of the leading causes of miscarriage and infertility in women, but its underlying reasons remain poorly understood. Implantation involves a s…
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Among the most serious health problems, infertility ranks third, after cancer and cardiovascular disease, in terms of its prevalence and impact on family quality of life.…
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Insight into the molecular and cellular mechanisms underpinning heart development is essential to our understanding of cardiovascular birth defects. Moreover, a similar b…
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Many species have the ability to undergo regenerative wound healing at varying degrees. Some are remarkably capable of whole-body regeneration, whereas others have a rege…
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Germ cells are crucial for the survival of our species. They are the only cells that undergo meiosis which is the genetic reassortment of chromosomes to produce the haplo…
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The objective of this collection is to expand the resources on endothelial cell reprogramming and endothelial cell heterogeneity analysis. The protocols that generate end…
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Morphogenesis is a complex event that establishes the correct tissue architecture. It is crucial for the specific functions of developed tissues. Investigations of spatio…
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Genetically Altered mice are the main stay of medical research, allowing us to delve deeper into the mechanics of gene function in health and disease. There are over 80,0…
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Biomedical research related to the molecular mechanisms of birth-defect development encompasses using animal models, in vitro techniques, brain organoids, and bioinformat…
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The knee joint is the most important joint of the human body, with complex anatomic structures and significant function. With the acceleration of population aging and the…
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There is an emerging interest in utilizing adipose tissue-derived stem cells (ASCs) for regenerative therapies and procedures. ASCs are generally not administered alone b…
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About 17% of animal protein consumed by human beings comes from fish. Aquaculture has been growing as one of the fastest-growing food sectors globally. However, aquacultu…
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Regulation of transcription in the terminally differentiated cells with respect to the role of a transcription factor binding dynamics is elusive. Many of the combinatori…
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The proposed edition will focus on the value of optogenetics as a new precision tool to explore diverse processes that regulate tissue and organ formation on multiple sca…
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Cardiovascular disease is one of the leading causes of death, especially in the Western world, and is also a major problem from an economic point of view. Due to the low …
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Organoids research has been prosperous in the last decade since it emergence in 2009 in Clevers’ lab. Different cell lines and culture methods combined into unique …
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Genome-wide chromatin remodelling occurs during all major cell fate transitions. A conserved and universal cell fate transition occurs during early development when a tot…
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The main physiological function of the lungs is to exchange oxygen and carbon dioxide between air and blood. At the same time, the lungs are also exposed to pathogens and…
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