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The study of protein-protein interactions is key to understanding the network of molecular interactions underlying biological effects, and defining how individual protein…
Integrative structural biology uses a large variety of biophysical methods that provide detailed knowledge of the atomic and molecular structure of macromolecules, isolat…
Proteins adopt different higher order structures (HOS) to enable their unique biological functions. Understanding the complexities of protein higher order structures and …
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Neutron scattering and diffraction techniques are uniquely sensitive to the position and dynamics of hydrogen atoms in materials and are a powerful tool for the character…
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Chromatin is a dynamic structure comprising DNA wrapped around histone proteins and compacted into 10,000 folds. For routine cellular processes, such as DNA replication, …
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Tuberculosis (TB) is one of the deadliest infectious killers in the world. This is intriguing because TB is curable to some extent. However, the simple answer to this int…
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Numerous diseases are caused by pathogen-derived proteins or endogenous proteins expressed typically or abnormally. In many diseases, ultrastructural imaging by electron …
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Type 2 diabetes and obesity now amount to a worldwide epidemic and predisposes people to numerous complications such as cardiovascular diseases, kidney diseases, and cert…
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Surface plasmon resonance-based assays have been a critical tool across the biological sciences for quantifying biomolecular interactions. These data have been invaluable…
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We propose a collection for JoVE that will describe contemporary methods of quantitating specific protein-RNA interactions. Over the last 5-10 years, there have been sign…
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With global warming, the adverse impact of environmental stress on plant growth and production will increase. To a minor degree, environmental perturbation may severely d…
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Porins are β-barrel structures extending to the outer membrane layer of Gram-negative and few Gram-positive bacteria. They act as aperture in the cellular membrane t…
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Pharmacology is a broad field encompassing the study of experimental and clinical pharmacology, toxicology, pharmaceutical medicine, and biomedical sciences. Pharmacologi…
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Natural products are a prolific source of chemical probes, having shed light on fundamental biological processes and therapeutics that have extended human life. Ribosomal…
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Robotic surgery has recently seen a tremendous increase in the range of its indications in colorectal surgery. Robotic surgery does not only offer better access to the na…
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A metabolome is a collection of small molecules, or metabolites, and their interactions within a biological system. Metabolomics is defined as the study of metabolites in…
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There is an increasing interest in understanding how cell metabolism contributes to pathogenesis in a variety of diseases like cancer, autoimmune, and infectious diseases…
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A growing number of studies continuously uncover the novel roles of methylation in human diseases. Currently, the link between methylation and cancer has been substantiat…
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The pursuit of controlling biological processes and interactions lies at the heart of biomolecular engineering. DNA-lipid conjugates are versatile tools in this regard. T…
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Targeted protein degradation (TPD) is a rapidly growing multidisciplinary field that transcends drug discovery, medicinal chemistry, chemical biology, pharmacology, biolo…
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Dietary phytochemicals are found in many plant-based foods such as vegetables, fruits, grains, nuts, oils, seeds, legumes, and beans. Epidemiological and clinical studies…
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DNA nanotechnology, from the concept of Nadrian Seeman in 1982, and the innovation by Paul Rothemund in 2006, has demonstrated significant progress in designing DNA nanos…
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There has been a dramatic increase in the approval of biologics by US regulators for the past decade. Biologics include nucleic acids, peptides, and proteins. Despite the…
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Peptides as a drug modality have attracted a great deal of attention, owing to their high degree of specific binding, synthetic accessibility, and ability to target flat …
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Integration of omics approaches such as genomics, transcriptomics, ionomics, epigenomics, proteomics, metabolomics, and phenomics in plant pathology has enhanced our unde…
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Contamination of land and water bodies with petroleum hydrocarbons (PHs) has been a global concern for many years. Although, various physicochemical techniques are in use…
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Bacteria are unicellular organisms and inhabit numerous environmental conditions on earth. Therefore, bacteria must immediately detect environmental cues and respond appr…
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Nanocarriers are powerful tools in addressing pharmaceutical and medical problems. These carriers can be utilized to solve issues ranging from toxicity, target transport,…
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No matter for commercial purposes or to go by human instinct, food processes have become more sophisticated to obtain a good appearance, smell, taste, and texture. To mee…
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The abiotic-biotic interface has been crucial to life since the beginning of time- starting with the formation of simple organic molecules on the surfaces of minerals. Si…
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Selenium (Se) is a trace element with a great variety of effects on the human health mainly due to its redox homeostasis. In the last decade, modification of small molecu…
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Nature evolution has produced the natural products with diverse structure targeting for biological macromolecule in living organisms. In the process of natural selection,…
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