Mechanizm wchłaniania leków: transport membranowy za pośrednictwem nośnika

Large lipid-insoluble drugs resembling amino acids, peptides, or glucose cannot dissolve in the lipid bilayer and pass through directly. Specialized carrier proteins bind these molecules and facilitate their transport across the membrane through either facilitated diffusion or active transport, enabling absorption despite their chemical properties.

Facilitated diffusion is a passive process using SLC transporters that move drugs down their concentration gradient without energy input. Active transport moves drugs against their concentration gradient and requires energy from ATP hydrolysis or electrochemical gradients, enabling absorption of drugs that would otherwise accumulate outside cells.

SLC transporters bind to drug molecules, undergo conformational changes, and release the drug on the opposite side of the membrane. This process can occur passively through facilitated diffusion or actively through secondary active transport, where the electrochemical gradient of another solute drives drug movement.

Primary active transport uses ABC transporters that directly hydrolyze ATP to generate energy for unidirectional drug efflux across the cell membrane. This energy-dependent mechanism actively pumps drugs out of cells against their concentration gradient, independent of other solute movements and transporter conformational changes.

Secondary active transport uses SLC transporters powered by the electrochemical potential created when another solute moves along its gradient. The drug couples to this solute movement, allowing uphill transport without direct ATP hydrolysis, occurring as either symport or antiport depending on directional coupling.

Symport moves the drug and coupled solute in the same direction across the membrane, while antiport moves them in opposite directions. Both mechanisms harness electrochemical gradients to transport drugs against concentration gradients through SLC transporters without requiring direct ATP hydrolysis.

Carrier-mediated transport determines whether lipid-insoluble drugs can be absorbed across cell membranes and enter systemic circulation. The efficiency of facilitated diffusion and active transport directly influences drug absorption rates and systemic availability, making transporter expression and function critical determinants of overall drug bioavailability.