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الفصل 4
مواقع ارتباط الجزىء
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their…
ترافق جزبئات البروتين
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most…
مواقع ترابط محفوظة من التغيير
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein…
ثابت الاتزان و قوة الترابط
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is…
العوامل المساعدة والإنزيمات المساعدة
Enzymes require additional components for proper function. There are two such classes of molecules: cofactors and coenzymes. Cofactors are metallic…
الضوابط التفارغية
Allosteric regulation of enzymes occurs when the binding of a molecule to a different location from the active site causes a change in enzymatic…
ارتباط الجزىء والاتصال
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the…
Allosteric Proteins-ATCase
Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism…
التحولات المتعاونة فى التفارغية
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand…
الفسفرة
The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These…
بروتين كايناز وفوسفاتاز
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation,…
جى تي باز ومنظمها
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as…
منظمات البروتين المرتبطة تساهميا
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an…
مركبات البروتين بأجزاء قابلة للتغيير
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s…
وظائف البروتين الميكانيكية
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical…
وظيفة البروتين البنيوى
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major…
شبكات البروتين
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other…
فحص البروتين كيناس النشاط مع راديولابيلد أتب
Protein kinases are able to govern large-scale cellular changes in response to complex arrays of stimuli, and much effort has been directed at…
تحليل البروتين أبنية ومجمعات البروتين-يجند بالتكامل الهيكلي الكتلي
Proteins are an important class of biological macromolecules that play many key roles in cellular functions including gene expression, catalyzing…
القياس الكمي لديناميات شبكة تفاعل البروتين باستخدام الترسيب المناعي المشترك المتعدد
Dynamic protein-protein interactions control cellular behavior, from motility to DNA replication to signal transduction. However, monitoring dynamic…

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