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第5章
DNA包装
Eukaryotes have large genomes compared to prokaryotes. In order to fit their genomes into a cell, eukaryotes must pack their DNA tightly inside the…
DNA(脱氧核糖核酸)作为遗传模板
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature.…
基因的组织
The genomes of eukaryotes can be structured in several functional categories. A strand of DNA is comprised of genes and intergenic regions. Genes…
染色体结构
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication. The centromere is a DNA…
染色体复制
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone…
核小体
DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA…
核小体核心颗粒
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies…
核小体重塑
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA…
染色质包装
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a…
染色体核型分析
Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated…
位置效应变异
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and…
组蛋白修饰
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational…
染色质修饰的传播
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed…
笔刷染色体
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined…
聚乙烯染色体
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani…
染色体着丝粒(中节)的组蛋白变体
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that…
染色质结构的遗传
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the…
染色质的多种形式
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted…
Heterochromatin
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted…
染色质位置影响基因表达
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside…
产生和人类INO80染色质重塑复合物及其亚纯化
INO80 chromatin remodeling complexes regulate nucleosome dynamics and DNA accessibility by catalyzing ATP-dependent nucleosome remodeling. Human…
从<em>酿酒酵母</em>中组蛋白修饰的染色质沉淀 (芯片)
Histone post-translational modifications (PTMs), such as acetylation, methylation and phosphorylation, are dynamically regulated by a series of…
从青蛙和蝾螈的卵母细胞活巨Lampbrush染色体的分离
We describe methods for studying the giant transcriptionally active lampbrush chromosomes (LBCs) found in the oocyte, or unlaid egg, of frogs and…

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