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Capitolo 10
Espressione genica specifica delle cellule
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same…
La regolazione dell'espressione avviene in più passaggi
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves…
Sequenze di regolazione Cis
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These…
Legame cooperativo dei regolatori di trascrizione
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences…
Attivatori e repressori trascrizionali procariotici
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the…
Operone
Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related…
La regione del promotore eucariotico
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start…
Co-attivatori e Co-repressori
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in…
Attivatori di trascrizione eucariotica
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate…
Inibitori della trascrizione eucariotica
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding…
Controllo genico combinato
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of…
Cellule staminali pluripotenti indotte
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific…
Principali regolatori di trascrizione
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often…
Regolazione epigenetica
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases…
Imprinting genomico ed ereditarietà
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both…
Identificare i siti di fattore di trascrizione Olig2 associazione genomico in acutamente purificato PDGFRα + cellule di immunoprecipitazione della cromatina Low-cella ordinamento dell'analisi
In mammalian cells, gene transcription is regulated in a cell type specific manner by the interactions of transcriptional factors with genomic DNA.…
Una piattaforma di metil-Seq ratto per identificare i cambiamenti epigenetici connessi con l'esposizione di sforzo
As genomes of a wider variety of animals become available, there is an increasing need for tools that can capture dynamic epigenetic changes in these…
Profiling dell'espressione genica specifica del tipo di cella nel fegato del mouse
Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental…

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