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Bölüm 13
DNA Sarmalı
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most…
DNA Paketleme
Eukaryotes have large genomes compared to prokaryotes. In order to fit their genomes into a cell, eukaryotes must pack their DNA tightly inside the…
Genlerin Organizasyonu
The genomes of eukaryotes can be structured in several functional categories. A strand of DNA is comprised of genes and intergenic regions. Genes…
Karyotipleme
Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated…
Prokaryotlarda replikasyon
DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to…
Ökaryotlarda Replikasyon
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity…
Düzeltme
Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA…
Yanlış Eşleşme Tamiri
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires…
Nükleotid Eksizyon Onarımı
Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged DNA…
Mutasyonlar
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors.…
Transkripsiyon
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene…
Tercüme
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it…
Bakteriyel Dönüşüm
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied…
DNA Origami bir Bio-duyarlı Robot katlanması ve Karakterizasyonu
The DNA nanorobot is a hollow hexagonal nanometric device, designed to open in response to specific stimuli and present cargo sequestered inside.…
ChIP-ekzo Yöntem: Base Çifti Hassas Protein-DNA Etkileşimleri belirlenmesi
Chromatin immunoprecipitation (ChIP) is an indispensable tool in the fields of epigenetics and gene regulation that isolates specific protein-DNA…
DNA Onarım Protein Eylem Mekanizması Soruşturma Durduruldu akış Kinetiği Yöntemleri Uygulama
Transient kinetic analysis is indispensable for understanding the workings of biological macromolecules, since this approach yields mechanistic…
Nükleotid Eksizyon Onarımında DNA Lezyon Tanınması için Atomik Kuvvet Mikroskopi Araştırmaları
AFM imaging is a powerful technique for the study of protein-DNA interactions. This single molecule method allows the simultaneous resolution of…

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