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Chapter 15

Chapter 15

Survival Analysis

Introduction To Survival Analysis
Consider the following three examples from biomedical studies. First, in cancer research, the time from when a patient enters remission to their relapse …
Life Tables
A life table or a mortality table represents the survival patterns of a population. It comprises multiple columns, each serving a practical purpose, …
Survival Curves
Consider a graph of the cumulative probability of death plotted as age on the X axis versus the proportion dead on the Y axis for a specific year. This …
Actuarial Approach
Survival analysis assesses the time until an event such as death or treatment failure occurs. The actuarial or life table approach, adapted from actuarial …
Kaplan-Meier Approach
The Kaplan-Meier estimator estimates the survival function from lifetime data. It is primarily used in medical research to track patient survival after …
Assumptions of Survival Analysis
Survival analysis, a statistical method, evaluates the time until an event occurs. It is commonly used in medicine to analyze life expectancy. It is …
Comparing the Survival Analysis of Two or More Groups
Survival analysis evaluates the time until an event, like disease recurrence or death, utilizing techniques that account for censored data, where the …
The Mantel-Cox Log-Rank Test
The Mantel-Cox log-rank test is a nonparametric statistical method for comparing survival distribution curves between two groups. It is typically employed …
Applications of Life Tables
A life table, or mortality table, is a statistical tool that compiles a population's mortality characteristics, providing survival and death …
Cancer Survival Analysis
Cancer survival analysis measures the time from diagnosis or start of the treatment to an event like recurrence or death. This analysis is crucial for …
Hazard Rate
In a clinical study, the subjects or participants are observed over a time interval for an event, such as death, that occurs only once. Now, if a …
Hazard Ratio
The hazard ratio compares the hazard or risk of an event occurring at any given point in time between two groups. Consider λ(t) as a hazard rate at …
Truncation in Survival Analysis
In survival analysis, time is measured from the study start, ensuring all participants are observed from time zero until they die or are censored. But, …
Censoring Survival Data
In survival data, censoring leads to incomplete data, and it typically occurs when subjects experience an event before or after the study ends. …
Survival Tree
A survival tree is used to model and visualize the relationship between a set of covariates and the time until an event of interest occurs. It is …
Parametric Survival Analysis: Weibull and Exponential Methods
Weibull and exponential models are frequently used in survival analysis. A two-parameter Weibull distribution has a survival curve given as follows. Here, …
Methodology for Developing Life Tables for Sessile Insects in the Field Using the Whitefly, Bemisia tabaci, in Cotton As a Model System
Life tables provide a means of measuring the schedules of birth and death from populations over time. They also can be used to quantify the sources and …
Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy
Standard cytotoxicity assays, which require the collection of lysates or fixed cells at multiple time points, have limited sensitivity and capacity to …
Establishing a Competing Risk Regression Nomogram Model for Survival Data
The Kaplan–Meier method and Cox proportional hazards regression model are the most common analyses in the survival framework. These are relatively …