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Apolipoprotein A-I: The most abundant protein component of High density lipoproteins or Hdl. This protein serves as an acceptor for Cholesterol released from cells thus promoting efflux of cholesterol to Hdl then to the Liver for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for Lecithin cholesterol acyltransferase that forms Cholesterol esters on the Hdl particles. Mutations of this gene Apoa1 cause Hdl deficiency, such as in Familial alpha lipoprotein deficiency disease and in some patients with Tangier disease.

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

1Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, 2Robert M. Berne Cardiovascular Research Center, University of Virginia, 3Department of Biochemistry and Molecular Genetics, University of Virginia, 4Division of Cardiology, University of Pittsburgh School of Medicine

JoVE 59139


 Medicine

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

1Department of Anesthesiology, Medical College of Wisconsin, 2Clement J. Zablocki Veterans Affairs Medical Center, 3Department of Surgery, Division of Pediatric Surgery, Children's Research Institute, 4Department of Orthopedic Surgery, Medical College of Wisconsin, 5Deptarment of Anesthesiology, Clement J Zblocki Veteran Affairs Medical Center, 6Department of Medicine, Division of Cardiology, Medical College of Wisconsin

JoVE 55036


 Immunology and Infection

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