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Antigens, CD86: A costimulatory ligand expressed by Antigen-presenting cells that binds to Cd28 antigen with high specificity and to Ctla-4 antigen with low specificity. The interaction of Cd86 with Cd28 antigen provides a stimulatory signal to T-Lymphocytes, while its interaction with Ctla-4 antigen may play a role in inducing Peripheral tolerance.

Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood

1Division of Pediatrics, U.T. MD Anderson Cancer Center, 2Department of Stem Cell Transplantation and Cellular Therapy, U.T. MD Anderson Cancer Center

JoVE 50070

 Immunology and Infection
134
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